Compensatory Mechanisms Following Vestibular Loss

前庭丧失后的补偿机制

• 批准号: 7145719
• 负责人: RICHARD A. CLENDANIEL
• 金额: $ 7.78万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-19 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7145719
• 关键词: behavioral habituation /sensitization; brain injury; clinical research; exercise; gait; human subject; human therapy evaluation; medical rehabilitation related tag; nervous system disorder therapy; nervous system regeneration; neural degeneration; neuropsychological tests; patient oriented research; psychomotor reaction time; rehabilitation; saccades; vestibular apparatus; vestibuloocular reflex; visual perception; visual tracking

DESCRIPTION (provided by applicant): The long-term goals of this research are to understand the adaptive and compensatory capabilities of the gaze stability systems following vestibular lesions and to identify the mechanisms that drive the compensation process. An understanding of the adaptive/compensatory mechanisms will be pertinent to motor learning, a fundamental question in neuroscience, and will have practical implications for our understanding of how humans compensate for vestibular disorders. A functional, long-term outcome of this research will be the development of more appropriate rehabilitation strategies for patients with vestibular disorders. These rehabilitation strategies may serve as models for the rehabilitation of other neuromuscular movement disorders. The first aim of the study is to determine the mechanism(s) responsible for improvements in gaze stability during head movements following unilateral vestibular loss. Gaze stability during head movements will be measured using a computerized dynamic visual acuity (DVA) system. Eye movements will be recorded using a video based eye movement recording technique during the DVA test prior to and following the completion of a vestibular rehabilitation program. The eye movements for successful and unsuccessful trials will be characterized. The eye movements post-rehabilitation will be analyzed to determine if there has been an improvement in the vestibulo-ocular reflex gain, an increase in the use of vestibular catch-up saccades, and/or an increase in the use of anticipatory slow eye movements. The second aim of the study is to determine if there is a difference in the efficacy and nature of recovery in individuals with unilateral vestibular loss who are given a rehabilitation program consisting of either vestibular adaptation exercises or a program of vestibular habitation exercises. The recovery will be assessed using DVA, eye movement recording, measures of motion sensitivity, balance and gait function, as well as subjective measures of function and impairment.

描述（由申请人提供）：本研究的长期目标是了解前庭病变后凝视稳定系统的适应和代偿能力，并确定驱动代偿过程的机制。对适应/补偿机制的理解将与运动学习相关，这是神经科学的一个基本问题，并将对我们理解人类如何补偿前庭疾病具有实际意义。这项研究的一个功能性的、长期的结果将是为前庭疾病患者制定更合适的康复策略。这些康复策略可以作为其他神经肌肉运动障碍康复的模型。本研究的第一个目的是确定单侧前庭功能丧失后头部运动中凝视稳定性改善的机制。头部运动时的凝视稳定性将使用计算机动态视力（DVA）系统进行测量。在完成前庭康复计划之前和之后的DVA测试期间，将使用基于视频的眼动记录技术记录眼球运动。成功和不成功试验的眼球运动将被表征。将分析康复后的眼球运动，以确定前庭眼反射增益是否有所改善，前庭追赶扫视的使用是否有所增加，以及/或预期慢眼运动的使用是否有所增加。本研究的第二个目的是确定单侧前庭功能丧失患者接受由前庭适应训练或前庭居住训练组成的康复计划后，其恢复的效果和性质是否存在差异。恢复情况将通过DVA、眼动记录、运动灵敏度、平衡和步态功能测量以及功能和损伤的主观测量来评估。