Core--Health Outcomes

该计划项目更新的主要目标是了解环境颗粒污染与心血管生理、血液和生化结果的关系，反映可能解释污染与心脏发病率和死亡率之间已知关联的潜在机制。为了实现这些目标，我们将建立一个健康结果核心，其中包括动态心电图组件、新的血管/炎症组件以及用于安全跟踪和存储血液样本的第三个组件。健康成果核心的总体目标是： 1. 提供生理、血液和生化健康结果的集中、标准化、可比较的测量，包括： a.分析心率子项目生成的所有动态心电图 (AECG) 数据 变异性（自主神经功能的测量）、标准临床心电图结果和项目特定 根据最近对空气污染对动物和人类影响的调查（例如快速心律失常、ST 段变化），心脏心电图终点已被证明是有意义的 b. 2 型糖尿病和冠状动脉疾病受试者的血管结果（肱动脉直径、内皮依赖性血流介导的动脉扩张、内皮非依赖性血管舒张、脉搏波分析） c. 2 型糖尿病和冠状动脉疾病受试者心血管风险和糖尿病控制的血液学和生化测量 d.子项目的全身炎症和内皮激活的血液学和生化标志物 2. 提供血液样本的集中、安全存储和追踪。 3. 成为子项目心脏病学、血管疾病和糖尿病方面的专业知识资源。

A primary goal of this Program Project renewal is to understand the relation of ambient particle pollution to cardiovascular physiologic, hematologic and biochemical outcomes reflecting potential mechanisms that might explain the known associations of pollution with cardiac morbidity and mortality. To accomplish these objectives, we will establish a Health Outcomes Core with an Ambulatory ECG Component, a new Vascular/Inflammatory Component, and a third component for the secure tracking and storage of blood specimens. The overall objectives of The Health Outcomes Core will be: 1. To provide centralized, standardized, comparable measurement of physiologic, hematologic, and biochemical health outcomes including: a. Analysis of all ambulatory ECG (AECG) data generated by subprojects for heart rate variability (measure of autonomic function), standard clinical ECG outcomes, and project-specific cardiac ECG endpoints which have proved to be of interest based on recent investigations of the effects of air pollution in both animals and humans (e.g., tachyarrhythmias, ST-segment changes) b. Vascular outcomes (brachial artery diameter, endothelium-dependent flow-mediated arterial dilation endothelium non-dependent vasodilation, pulse-wave analysis) for Type 2 diabetic and coronary artery disease subjects c. Hematologic and biochemical measures of cardiovascular risk and diabetes control for Type 2 diabetic and coronary artery disease subjects d. Hematologic and biochemical markers of systemic inflammation and endothelial activation for subprojects 2. To provide centralized, secure storage and tracking of blood specimens. 3. To be a resource of expertise in cardiology, vascular disease, and diabetes for subprojects.