Core--Health Outcomes

本计划项目更新的主要目标是了解环境颗粒污染与心血管生理学、血液学和生化结果的关系，这些结果反映了可能解释污染与心脏病发病率和死亡率之间已知关联的潜在机制。为了实现这些目标，我们将建立一个健康结局核心，其中包括动态心电图组件、新的血管/炎症组件以及用于安全跟踪和储存血液样本的第三个组件。健康成果核心的总体目标是： 1.提供生理、血液学和生化健康结局的集中、标准化、可比测量，包括： a.分析子项目生成的所有动态心电图（AECG）数据的心率 变异性（自主神经功能的测量）、标准临床ECG结局和项目特异性 基于最近对空气污染对动物和人类的影响的研究已经证明是令人感兴趣的心脏ECG终点（例如，快速性心律失常，ST段改变） B. 2型糖尿病和冠心病受试者的血管结局（肱动脉直径、内皮依赖性血流介导的动脉舒张、内皮非依赖性血管舒张、脉搏波分析） C. 2型糖尿病和冠心病患者心血管风险和糖尿病控制的血液学和生化指标 D.子项目的全身炎症和内皮活化的血液学和生化标志物 2.提供集中、安全的血液样本存储和跟踪。 3.为子项目提供心脏病学、血管疾病和糖尿病方面的专业知识。

A primary goal of this Program Project renewal is to understand the relation of ambient particle pollution to cardiovascular physiologic, hematologic and biochemical outcomes reflecting potential mechanisms that might explain the known associations of pollution with cardiac morbidity and mortality. To accomplish these objectives, we will establish a Health Outcomes Core with an Ambulatory ECG Component, a new Vascular/Inflammatory Component, and a third component for the secure tracking and storage of blood specimens. The overall objectives of The Health Outcomes Core will be: 1. To provide centralized, standardized, comparable measurement of physiologic, hematologic, and biochemical health outcomes including: a. Analysis of all ambulatory ECG (AECG) data generated by subprojects for heart rate variability (measure of autonomic function), standard clinical ECG outcomes, and project-specific cardiac ECG endpoints which have proved to be of interest based on recent investigations of the effects of air pollution in both animals and humans (e.g., tachyarrhythmias, ST-segment changes) b. Vascular outcomes (brachial artery diameter, endothelium-dependent flow-mediated arterial dilation endothelium non-dependent vasodilation, pulse-wave analysis) for Type 2 diabetic and coronary artery disease subjects c. Hematologic and biochemical measures of cardiovascular risk and diabetes control for Type 2 diabetic and coronary artery disease subjects d. Hematologic and biochemical markers of systemic inflammation and endothelial activation for subprojects 2. To provide centralized, secure storage and tracking of blood specimens. 3. To be a resource of expertise in cardiology, vascular disease, and diabetes for subprojects.