AIR POLLUTION AND CARDIAC VULNERABILITY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这一合作项目是与NIH/NIEHS P01 ES09825项目的研究人员合作进行的，该项目名为环境颗粒物对人类心脏脆弱性的影响。这笔赠款的目的是确定暴露在环境空气污染物中的影响可能导致心血管事件的机制。其目的是：1)表征高危人群的生理状态；2)充分详细地监测暴露，以表征和量化假定的环境因素；3)对心脏功能进行详细和适当的持续测量，以评估心脏的自主神经反应；以及4)将这些潜在的发现与在暴露于浓缩空气颗粒的动物中发现的结果相关联。Physionet的研究人员正在使用资源中心开发的新方法帮助分析心脏搏动间期时间序列，以检验以下假设：增加空气污染水平可能会降低心脏迷走神经张力，降低心率调节的复杂性，从而增加不良心血管事件的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This collaborative project is being conducted with investigators from the Program Project NIH/NIEHS P01 ES09825, Effects of ambient particles on human cardiac vulnerability. The goal of this grant is to identify mechanisms whereby effects of exposure to ambient air pollutants could result in cardiovascular events. The aims are: 1) characterize the physiologic state of at-risk groups; 2) monitor exposure in sufficient detail to characterize and quantify the putative environmental agents; 3) make detailed and appropriately sustained measures of cardiac function that are relevant to assessing the autonomic response of the heart; and 4) correlate these potential findings with those found in animals exposed to concentrated air particles. PhysioNet investigators are helping to analyze cardiac interbeat interval time series using new methods developed at the Resource to test the hypothesis that increasing levels of air pollution may reduce cardiac vagal tone and decrease the complexity of heart rate regulation, thereby increasing risk of adverse cardiovascular events.