AIR POLLUTION AND CARDIAC VULNERABILITY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This collaborative project is being conducted with investigators from the Program Project NIH/NIEHS P01 ES09825, Effects of ambient particles on human cardiac vulnerability. The goal of this grant is to identify mechanisms whereby effects of exposure to ambient air pollutants could result in cardiovascular events. The aims are: 1) characterize the physiologic state of at-risk groups; 2) monitor exposure in sufficient detail to characterize and quantify the putative environmental agents; 3) make detailed and appropriately sustained measures of cardiac function that are relevant to assessing the autonomic response of the heart; and 4) correlate these potential findings with those found in animals exposed to concentrated air particles. PhysioNet investigators are helping to analyze cardiac interbeat interval time series using new methods developed at the Resource to test the hypothesis that increasing levels of air pollution may reduce cardiac vagal tone and decrease the complexity of heart rate regulation, thereby increasing risk of adverse cardiovascular events.