Accessing 3-Alkyl 3-Amino Oxetanes by Carbonyl Alkylative Amination

通过羰基烷基化胺化获得 3-烷基 3-氨基氧杂环丁烷

• 批准号: 2638334
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2638334
• 关键词: Accessing; Alkyl; Amino; Oxetanes; Carbonyl

Year 1: General skills training and lab rotationsYears 2 to 4: The primary aim of this project is to synthesise a broad range of 3-alkyl 3-amino oxetanes by a carbonyl CAA reaction. This two-step method would proceed by a condensation between oxetan-3-one and a selected amine to give an oxetanyl imine, followed by an imine alkylation step with a selected alkyl iodide to yield the corresponding 3-alkyl 3-amino oxetane products. This proposed route to 3-alkyl 3-amino oxetanes by a CAA reaction would be superior to prior routes due to the range of amines and alkyl groups which could be incorporated into the products.

二至四年级：本项目的主要目的是通过羰基CAA反应合成广泛的3-烷基3-氨基氧烷。这种两步法首先在氧乙烷-3- 1和选定的胺之间缩合得到氧乙基亚胺，然后与选定的碘化烷基进行亚胺烷基化，得到相应的3-烷基3-氨基氧乙烷产品。通过CAA反应生成3-烷基3-氨基氧烷的方法优于先前的方法，因为可以将胺和烷基纳入产品的范围。