Accessing 3-Alkyl 3-Amino Oxetanes by Carbonyl Alkylative Amination

第一年：一般技能培训和实验室轮换第2年至第4年：该项目的主要目的是通过羰基CAA反应合成广泛的3-烷基3-氨基氧杂环丁烷。该两步法将通过氧杂环丁烷-3-酮与所选胺之间的缩合进行，以得到氧杂环丁烷基亚胺，然后用所选烷基碘进行亚胺烷基化步骤，以得到相应的3-烷基3-氨基氧杂环丁烷产物。由于可以引入产物中的胺和烷基的范围，通过CAA反应得到3-烷基3-氨基氧杂环丁烷的这一建议路线将优于现有路线上级。

Year 1: General skills training and lab rotationsYears 2 to 4: The primary aim of this project is to synthesise a broad range of 3-alkyl 3-amino oxetanes by a carbonyl CAA reaction. This two-step method would proceed by a condensation between oxetan-3-one and a selected amine to give an oxetanyl imine, followed by an imine alkylation step with a selected alkyl iodide to yield the corresponding 3-alkyl 3-amino oxetane products. This proposed route to 3-alkyl 3-amino oxetanes by a CAA reaction would be superior to prior routes due to the range of amines and alkyl groups which could be incorporated into the products.