RF Coils for Parallel MRI/MRS in vivo at High Fields

用于高场体内并行 MRI/MRS 的射频线圈

• 批准号: 7351972
• 负责人: XIAOLIANG ZHANG
• 金额: $ 33.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7351972
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; human subject; image enhancement; magnetic field; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; radiowave radiation

DESCRIPTION (provided by applicant): High and ultra-high field (3-9.4 Tesla) magnetic resonance imaging and spectroscopy (MRI/MRS) has been proven to be fundamentally advantageous due to their intrinsically high sensitivity. Recently, with the advent of new reconstruction algorithms such as SENSE and SMASH, parallel imaging, a fast imaging technique introduced some 20 years ago has been revived and has become practical and robust. This technique can dramatically reduce the minimum data acquisition time without sacrificing sensitivity. A technique combining parallel imaging with high-field MR is desired and will be ideal because it possesses both the advantages of fast acquisition time and high sensitivity. However, due to high operating frequencies at high fields, both parallel imaging and high-field MR confront RF coil design challenges such as increased radiation losses, difficult to achieve coil decoupling, increased coil/subject interactions, and complicated design and operation. These challenges have become a major obstacle for further development of parallel imaging at high fields. Therefore, we propose a comprehensive project in this application based on our newly developed microstrip transmission line (MTL) coil design concept. The major goals will be focused on (i) development of a wide variety of efficient high-frequency RF coil arrays for in-vivo high-field parallel imaging using the MTL concept; and (ii) the establishment of a simulation, modeling a wide variety of parallel MTL coil arrays for the analysis of resonant frequencies, decoupling and B1 and E fields, numerically. The proposed coil arrays are characterized by unmatched advantages of (i) a completely distributed circuit design, (ii) a high Q factor and better sensitivity, (iii) unique and efficient decoupling mechanisms, and (iv) simple and compact coil design, with easy fabrication and low cost. Successful outcomes from this research will provide a robust solution to RF coil array designs for parallel imaging at high fields and result in significant technological advances in high-field RF coil array engineering. They will be important to the future success of in vivo high-field parallel MRI/MRS.

描述（由申请人提供）： 高场和超高场（3-9.4特斯拉）磁共振成像和波谱（MRI/MRS）由于其固有的高灵敏度而被证明是基本上有利的。最近，随着诸如SENSE和SMASH、并行成像等新的重建算法的出现，大约20年前引入的快速成像技术已经复兴，并且已经变得实用和鲁棒。这种技术可以在不牺牲灵敏度的情况下显著减少最小数据采集时间。一种将并行成像与高场MR相结合的技术是期望的，并且将是理想的，因为它具有快速采集时间和高灵敏度的优点。然而，由于高场下的高操作频率，并行成像和高场MR都面临RF线圈设计挑战，诸如增加的辐射损耗、难以实现线圈去耦、增加的线圈/对象相互作用以及复杂的设计和操作。这些挑战已经成为进一步发展高场并行成像的主要障碍。因此，我们提出了一个全面的项目，在这个应用程序的基础上，我们新开发的微带传输线（MTL）线圈的设计概念。主要目标将集中在（i）使用MTL概念开发用于体内高场并行成像的各种高效高频RF线圈阵列;以及（ii）建立模拟，对各种并行MTL线圈阵列进行建模，用于分析谐振频率、去耦以及B1和E场。所提出的线圈阵列的特征在于以下无与伦比的优点：（i）完全分布式电路设计，（ii）高Q因子和更好的灵敏度，（iii）独特且有效的解耦机制，以及（iv）简单且紧凑的线圈设计，具有容易制造和低成本。这项研究的成功成果将为高场并行成像的RF线圈阵列设计提供一个强大的解决方案，并导致高场RF线圈阵列工程的重大技术进步。它们对于体内高场并行MRI/MRS的未来成功将是重要的。