Simulaneous Dual Isotope SPECT w/Cross Talk Correction

描述（由申请人提供）：SPECT的一个独特功能是能够使用两种用不同同位素标记的药物，发射不同能量的光子，以同时测量不同的生理过程。从两个同位素同时采集投影数据具有允许测量两个潜在相关过程（例如，静息和应激灌注或灌注和受体密度）。这可能会增加额外的诊断信息，此外，还有实际优势，例如增加患者吞吐量、消除配准问题以及导致两项研究中常见的患者运动。然而，由于患者和伽马相机中的散射以及常规伽马相机的差的能量分辨率，双同位素采集将导致两组投影数据的串扰污染。在这项工作中，我们假设，我们可以开发的方法，同时采集和重建双同位素图像，可以减少这种串扰的影响，图像的诊断图像质量接近，如果他们将单独收购的点。我们选择专注于两个特定的应用：双同位素Tc-99 m/ TI-201负荷/静息心肌灌注SPECT和双同位素Tc-99 m/I-123脑SPECT，主要强调Tc-99 m/TI-201成像。为此，我们建议：（1）开发优化和评价TI-201/Tc-99 m同步显像的方法;（2）开发和实施改进的双同位素SPECT串扰补偿方法;（3）开发优化的Tc-99 m/TI-201心肌灌注SPECT采集方法;（4）使用模拟数据和数学观测器评价这些方法;（5）采用体模实验和图像质量的定量测量来评价同时双同位素Tc-99 m/I-123 SPECT：（6）对同时和单独采集双同位素静息/负荷心肌灌注SPECT进行临床评价。鉴于该手术的频率以及患者舒适度和临床吞吐量的显著改善，我们认为这将对临床实践产生重大影响。我们还将开发用于同时进行Tc-99 m/I-123脑成像的技术，这可能在新的I-123和Tc-99 m标记的脑剂开发和上市时证明是重要的。

DESCRIPTION (provided by applicant): One unique feature of SPECT is the ability to use two pharmaceuticals labeled with different isotopes emitting photons with different energies to make simultaneous measurements of different physiological processes. Simultaneous acquisition of projection data from two isotopes has the advantage that it allows measurement of two potentially related processes (e.g., rest and stress perfusion or perfusion and receptor density) at the same time. This may add additional diagnostic information and, in addition, there are practical advantages such as increased patient throughput, elimination of problems with registration and results in common patient motion in the two studies. However, due to scatter in the patient and gamma camera and the poor energy resolution of conventional gamma cameras, dual isotope acquisition will result in cross talk contamination of the two sets of projection data. In this work we hypothesize that we can develop methods for simultaneously acquiring and reconstructing dual isotope images that can reduce the effects of this cross talk to the point where the images have diagnostic image quality close to that which they would have if acquired separately. We have chosen to focus on two specific applications: dual isotope Tc-99m/ TI-201 stress/rest myocardial perfusion SPECT and dual isotope Tc-99m/I-123 brain SPECT, with major emphasis on Tc-99m/TI-201 imaging. Toward this end we propose to: (1) Develop methods for optimizing and evaluating simultaneous TI-201/Tc-99m imaging (2) Develop and implement improved cross talk compensation methods for simultaneous dual isotope SPECT (3) Develop optimized acquisition methods for Tc-99m/TI-201 myocardial perfusion SPECT; (4) To evaluate these methods using simulated data and mathematical observers; (5) To evaluate simultaneous dual isotope Tc-99m/I-123 SPECT using phantom experiments and quantitative measures of image quality; and (6) To perform a clinical evaluation of simultaneous and separate acquisition of dual isotope rest/stress myocardial perfusion SPECT. Given the frequency with which this procedure is performed and the significant improvement in both patient comfort and clinical throughput, we believe this would have a substantial impact on clinical practice. We also will have developed techniques for simultaneous Tc-99m/I-123 brain imaging that may prove important as new I-123 and Tc-99m labeled brain agents are developed and marketed.