Decarboxylative fluorination of aromatic carboxylic acids

芳香族羧酸的脱羧氟化

• 批准号: 2660641
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2660641
• 关键词: Decarboxylative; fluorination; aromatic; carboxylic; acids

Objective:This project will investigate the development of synthetic methods for the synthesis of fluorinated aromatic compounds via C-H and decarboxylative activation.Approach:We will develop novel fluorinating reagents capable of achieving fluorination aromatic compounds by taking advantage of the reactivity of carboxylic acid functional groups present in the molecules.A series of fluorinating reagents will be designed with the help of computational studies, synthesized and tested. Successful reagents will be further investigated to reveal their scope and potential as well as their applications to industrially relevant compounds, particularly in the pharmaceutical arena.Remit:This project falls within the areas of Catalysis and Synthetic Organic Chemistry

目的：研究碳氢活化法和脱羧活化法合成含氟芳香族化合物的新方法。方法：我们将开发新型氟化试剂，利用分子中羧酸官能团的反应性，实现芳香族化合物的氟化。一系列的氟化试剂将在计算研究的帮助下设计，合成和测试。将进一步研究成功的试剂，以揭示它们的范围和潜力，以及它们在工业相关化合物中的应用，特别是在制药领域。职权范围：该项目属于催化和合成有机化学领域