Using an intestinal organoid platform to model Crohn's disease and go on to use this model as a platform for drug discovery

使用肠道类器官平台来模拟克罗恩病，并继续使用该模型作为药物发现的平台

• 批准号: 2662273
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2662273
• 关键词: Using; intestinal; organoid; platform; model

We are using a recently developed a 3D in vitro model of inflammatory bowel disease (IBD) using primary tissue biopsy from patients with IBD. These are also referred to as "mini-intestines" and allow us to model complex biological interactions that drive IBD. We shall be using this as a platform for disease modelling and drug discovery. This work shall contribute to furthering the understanding of IBD and the discovery of potential therapeutic applications for improving the lives of those suffering with this condition.

我们正在使用最近开发的炎症性肠病（IBD）的3D体外模型，该模型使用来自IBD患者的原发性组织活检。这些也被称为“微型肠道”，使我们能够模拟驱动IBD的复杂生物相互作用。我们将把它作为疾病建模和药物发现的平台。这项工作将有助于进一步了解IBD，并发现潜在的治疗应用，以改善患有这种疾病的人的生活。