Sleep and Daytime Functioning in Chronic Kidney Disease

慢性肾脏病的睡眠和日间功能

• 批准号: 7096644
• 负责人: Mark Lynn Unruh
• 金额: $ 15.35万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7096644
• 关键词: attention; behavioral /social science research tag; blood tests; chronic disease /disorder; clinical research; cognition; comorbidity; computer data analysis; disease /disorder model; disease /disorder proneness /risk; electroencephalography; evaluation /testing; hemodialysis; human subject; interview; kidney disorder; kidney transplantation; medical records; patient oriented research; performance; polysomnography; psychic activity level; quality of life; questionnaires; sleep apnea

DESCRIPTION (provided by applicant): Poor sleep and fatigue are commonly encountered in the practice of nephrology. In the general population, sleep studies using polysomnography show a substantial prevalence of sleep disordered breathing and other causes of sleep fragmentation in healthy adults that clearly contribute to sleepiness and fatigue, hypertension and cardiovascular disease. Potentially, such disorder could contribute to the very high rates of morbidity and mortality in the chronic kidney disease population. The general hypothesis for the proposed research program is that kidney failure is related to sleep disorders and these sleep disorders impact on daytime functioning. The Principal Investigator has designed a rigorous training program that will provide him with the necessary research skills, hands-on mentoring experiences, and content area expertise to develop into an independent investigator in the field of sleep and daytime functioning in chronic kidney disease. He will take courses designed to provide him the statistical, study design, and measurement methodology to carry out original research. His sponsors have extensive experience in clinical epidemiology, dialysis outcomes research, sleep disorders epidemiology and functioning outcomes methodology and are committed to his career development. The few preliminary studies using polysomnography suggest that sleep disorders may affect the majority in dialysis patients. The proposed study is designed to evaluate the full spectrum of both objectively assessed and self-reported sleep disorders and evaluate daytime functioning before and after kidney transplantation. The Specific Aims are 1) To characterize sleep and daytime functioning in persons with advanced kidney disease and on hemodialysis 2) To characterize changes in sleep and daytime functioning in persons after kidney transplantation. Statistical power demonstrates that the proposed study has an adequate sample size to assess each aim and a pilot project has demonstrated the feasibility of recruiting patients with chronic kidney disease for sleep and daytime functioning assessments. The team of experienced mentors and consulting scientists will monitor his progress in completing his project and his career development. The proposed training program and research projects will serve as a foundation for future projects to improve the sleep and daytime functioning in persons with chronic kidney disease.

描述（由申请人提供）： 睡眠不佳和疲劳是肾脏病学实践中常见的情况。在一般人群中，使用多导睡眠图进行的睡眠研究表明，健康成年人普遍存在睡眠呼吸障碍和其他导致睡眠碎片化的原因，这显然会导致嗜睡和疲劳、高血压和心血管疾病。这种疾病可能会导致慢性肾病人群的发病率和死亡率非常高。拟议研究计划的一般假设是，肾衰竭与睡眠障碍有关，而这些睡眠障碍会影响白天的功能。首席研究员设计了严格的培训计划，将为他提供必要的研究技能、实践指导经验和内容领域专业知识，以发展成为慢性肾脏病睡眠和日间功能领域的独立研究者。他将参加旨在为他提供开展原创研究所需的统计、研究设计和测量方法的课程。他的资助者在临床流行病学、透析结果研究、睡眠障碍流行病学和功能结果方法方面拥有丰富的经验，并致力于他的职业发展。使用多导睡眠图的少数初步研究表明，睡眠障碍可能影响大多数透析患者。拟议的研究旨在评估客观评估和自我报告的睡眠障碍的全部范围，并评估肾移植前后的日间功能。具体目标是 1) 表征晚期肾病和血液透析患者的睡眠和日间功能 2) 表征肾移植后患者睡眠和日间功能的变化。统计功效表明，拟议的研究有足够的样本量来评估每个目标，并且试点项目已经证明了招募慢性肾病患者进行睡眠和日间功能评估的可行性。由经验丰富的导师和咨询科学家组成的团队将监控他完成项目的进度和职业发展。拟议的培训计划和研究项目将为未来改善慢性肾病患者的睡眠和日间功能的项目奠定基础。