Sleep and Daytime Functioning in Chronic Kidney Disease

慢性肾脏病的睡眠和日间功能

• 批准号: 7477969
• 负责人: Mark Lynn Unruh
• 金额: $ 12.37万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7477969
• 关键词: Adult; Affect; Area; Attention; Cardiovascular Diseases; Chronic Kidney Failure; Cognitive; Commit; Consult; Development; Dialysis patients; Dialysis procedure; Disease; End stage renal failure; Epidemiology; Fatigue; Follow-Up Studies; Foundations; Future; General Population; Hand; Hemodialysis; High Prevalence; Hypertension; Kidney Diseases; Kidney Failure; Kidney Transplantation; Lead; Living Donors; Measurement; Mentors; Methodology; Monitor; Morbidity - disease rate; Nephrology; Nocturnal Myoclonus Syndrome; Outcome; Outcomes Research; Participant; Patient Self-Report; Patients; Performance; Persons; Physical Dialysis; Pilot Projects; Polysomnography; Population; Prevalence; Principal Investigator; Quality of life; Range; Rate; Recruitment Activity; Renal function; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Restless Legs Syndrome; Role; Sample Size; Scientist; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep Fragmentations; Study Subject; Training Programs; Transplantation; Well in self; career; clinical epidemiology; cognitive function; design; experience; health related quality of life; hypnotic; improved; limb movement; mortality; programs; skills

DESCRIPTION (provided by applicant): Poor sleep and fatigue are commonly encountered in the practice of nephrology. In the general population, sleep studies using polysomnography show a substantial prevalence of sleep disordered breathing and other causes of sleep fragmentation in healthy adults that clearly contribute to sleepiness and fatigue, hypertension and cardiovascular disease. Potentially, such disorder could contribute to the very high rates of morbidity and mortality in the chronic kidney disease population. The general hypothesis for the proposed research program is that kidney failure is related to sleep disorders and these sleep disorders impact on daytime functioning. The Principal Investigator has designed a rigorous training program that will provide him with the necessary research skills, hands-on mentoring experiences, and content area expertise to develop into an independent investigator in the field of sleep and daytime functioning in chronic kidney disease. He will take courses designed to provide him the statistical, study design, and measurement methodology to carry out original research. His sponsors have extensive experience in clinical epidemiology, dialysis outcomes research, sleep disorders epidemiology and functioning outcomes methodology and are committed to his career development. The few preliminary studies using polysomnography suggest that sleep disorders may affect the majority in dialysis patients. The proposed study is designed to evaluate the full spectrum of both objectively assessed and self-reported sleep disorders and evaluate daytime functioning before and after kidney transplantation. The Specific Aims are 1) To characterize sleep and daytime functioning in persons with advanced kidney disease and on hemodialysis 2) To characterize changes in sleep and daytime functioning in persons after kidney transplantation. Statistical power demonstrates that the proposed study has an adequate sample size to assess each aim and a pilot project has demonstrated the feasibility of recruiting patients with chronic kidney disease for sleep and daytime functioning assessments. The team of experienced mentors and consulting scientists will monitor his progress in completing his project and his career development. The proposed training program and research projects will serve as a foundation for future projects to improve the sleep and daytime functioning in persons with chronic kidney disease.

描述(由申请人提供)： 在肾脏病的实践中，睡眠不佳和疲劳是很常见的。在普通人群中，使用多导睡眠图进行的睡眠研究表明，在健康的成年人中，睡眠呼吸紊乱和其他睡眠碎片的原因相当普遍，这些原因显然会导致嗜睡和疲劳、高血压和心血管疾病。这种疾病可能会导致慢性肾脏疾病人群的发病率和死亡率非常高。拟议研究项目的总体假设是，肾衰竭与睡眠障碍有关，这些睡眠障碍会影响白天的功能。首席调查员设计了严格的培训计划，将为他提供必要的研究技能、实践指导经验和内容领域的专业知识，以发展成为慢性肾脏疾病睡眠和日间功能领域的独立调查员。他将选修旨在为他提供统计学、研究设计和测量方法的课程，以开展原创性研究。他的赞助商在临床流行病学、透析结果研究、睡眠障碍流行病学和功能结果方法学方面拥有丰富的经验，并致力于他的职业发展。少数使用多导睡眠图的初步研究表明，睡眠障碍可能会影响大多数透析患者。这项拟议的研究旨在评估客观评估和自我报告的睡眠障碍的全部范围，并评估肾移植前后的日间功能。其具体目的是1)描述晚期肾病患者和血液透析患者的睡眠和日间功能；2)描述肾移植后患者的睡眠和日间功能的变化。统计力量表明，拟议的研究有足够的样本量来评估每个目标，一个试点项目已经证明了招募慢性肾脏疾病患者进行睡眠和日间功能评估的可行性。由经验丰富的导师和咨询科学家组成的团队将监督他在完成项目和职业发展方面的进展。拟议的培训计划和研究项目将作为未来改善慢性肾脏疾病患者睡眠和日间功能的项目的基础。

项目成果

Health-related quality of life in hypertension, chronic kidney disease, and coexistent chronic health conditions.

• DOI: 10.1053/j.ackd.2010.04.002
• 发表时间: 2010-07-01
• 期刊: Advances in chronic kidney disease
• 影响因子: 2.9
• 作者: Soni, Ritu K;Porter, Anna C;Unruh, Mark L
• 通讯作者: Unruh, Mark L

Health-related quality of life in nephrology research and clinical practice.

肾脏病学研究和临床实践中与健康相关的生活质量。

• DOI: 10.1111/j.1525-139x.2005.18206.x
• 发表时间: 2005
• 期刊: Seminars in dialysis.
• 作者: Unruh,MarkL;Weisbord,StevenD;Kimmel,PaulL
• 通讯作者: Kimmel,PaulL

Sleep apnea and dialysis therapies: things that go bump in the night?

睡眠呼吸暂停和透析治疗：晚上会发生什么事情？

• DOI: 10.1111/j.1542-4758.2007.00203.x
• 发表时间: 2007
• 期刊: Hemodialysis international. International Symposium on Home Hemodialysis
• 作者: Unruh,MarkL

Sleep disordered breathing in patients with chronic kidney disease.

慢性肾病患者的睡眠呼吸障碍。

• 发表时间: 2010
• 期刊: The Indian journal of medical research
• 作者: Mavanur,Manju;Sanders,Mark;Unruh,Mark
• 通讯作者: Unruh,Mark

Kidney transplantation in elderly people: the influence of recipient comorbidity and living kidney donors.

老年人肾移植：受者合并症和活体肾捐赠者的影响。

• DOI: 10.1111/j.1532-5415.2007.01542.x
• 发表时间: 2008
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Wu,Christine;Shapiro,Ron;Tan,Henkie;Basu,Amit;Smetanka,Cynthia;Morgan,Claire;Shah,Nirav;McCauley,Jerry;Unruh,Mark
• 通讯作者: Unruh,Mark