PH-Responsive Micelles for Controlled Enzyme Inhibitor Release

在这个项目中，我们将设计ph响应胶束，装载抗癌剂SAHA，在肿瘤部位靶向有效的药物递送。组蛋白去乙酰化酶（hdac）因其在基因表达和肿瘤转移中的作用而成为肿瘤治疗中一类重要的分子靶点。SAHA是一种HDAC抑制剂，用于治疗t细胞淋巴瘤。尽管有好处，但SAHA已被证明具有脱靶效应，包括潜在的遗传毒性。在这个项目中，我们将生产SAHA的递送系统，使活性分子只在肿瘤上产生。为了选择性地将药物输送到肿瘤中，我们将开发胶束，在较低的pH值下释放SAHA，与典型的细胞外环境相比，肿瘤的还原环境更强。该项目包括抑制剂合成、胶束合成、胶束分析和生物测试。

In this project, we will design pH-responsive micelles, loaded with the anticancer agent SAHA, to target effective drug deliver at the tumour site. The histone-deacetylase enzymes (HDACs) are an important class of molecular targets in cancer therapy, due to their role in gene expression and cancer metastasis. SAHA is a HDAC inhibitor used to treat T-cell lymphoma. Despite its benefits, SAHA has been shown to have off-target effects, including potential genotoxicity. In this project, we will produce delivery systems for SAHA that lead to active molecule only at the tumour. To selectively deliver the drug to the tumour, we will develop micelles that release the SAHA at the lower pH and more reducing environment of the tumour compared to the typical extracellular environment. The project comprises inhibitor synthesis, micelle synthesis, micelle analysis and biological testing.