PH-Responsive Micelles for Controlled Enzyme Inhibitor Release

在这个项目中，我们将设计pH响应性胶束，负载抗癌剂SAHA，以靶向肿瘤部位的有效药物输送。组蛋白脱乙酰酶(HDACs)在基因表达和肿瘤转移中起重要作用，是肿瘤治疗中一类重要的分子靶点。SAHA是一种用于治疗T细胞淋巴瘤的HDAC抑制剂。尽管SAHA有好处，但已被证明具有非靶标效应，包括潜在的遗传毒性。在这个项目中，我们将为SAHA生产仅在肿瘤处产生活性分子的递送系统。为了选择性地将药物输送到肿瘤，我们将开发胶束，与典型的细胞外环境相比，胶束可以在较低的pH和更低的肿瘤还原环境下释放SAHA。该项目包括缓蚀剂合成、胶束合成、胶束分析和生物测试。

In this project, we will design pH-responsive micelles, loaded with the anticancer agent SAHA, to target effective drug deliver at the tumour site. The histone-deacetylase enzymes (HDACs) are an important class of molecular targets in cancer therapy, due to their role in gene expression and cancer metastasis. SAHA is a HDAC inhibitor used to treat T-cell lymphoma. Despite its benefits, SAHA has been shown to have off-target effects, including potential genotoxicity. In this project, we will produce delivery systems for SAHA that lead to active molecule only at the tumour. To selectively deliver the drug to the tumour, we will develop micelles that release the SAHA at the lower pH and more reducing environment of the tumour compared to the typical extracellular environment. The project comprises inhibitor synthesis, micelle synthesis, micelle analysis and biological testing.