Development of Environmentally-responsive Polymer Micelles Comprising of Molecular Assembly beta-Glucans with Physiological Activities and Their Medical Evolution

具有生理活性的由分子组装β-葡聚糖构成的环境响应性聚合物胶束的研制及其医学进展

• 批准号: 23550199
• 负责人: YAJIMA Hirofumi
• 金额: $ 3.33万
• 依托单位: Tokyo University of Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23550199/
• 关键词: β－グルカン; キトサン; カードラン; ヨウ素錯体; 高分子ミセル; 環境応答性; 薬物キャリヤー; β-グルカン; 高分子ナノゲル

Beta-glucans such as chitosan and curdlan have an effective physiological activity. However, a significant drawback of insolubility in neutral water exists for the practical use of their beta-glucans. In order to develop promising medical-nanomaterials working as drug carrier with their beta-glucans involved in overcoming the drawback, we have intended the graft (g) and block (b) type-copolymerization of their beta-glucans with hydrophilic and biocompatible polymers, polyethylene glycol and temperature-responsive poly(N-isopropylacrylamide). As a result, some g- and b-type copolymers soluble in neutral aqueous solution were succeed to be synthesized, and then, the molecular assembly complexation of the copolymers with iodine gave rise to assume environmentally-responsive nano-particles with a size of ca. 50-100 nm, containing iodine in internal aggregated-core. Consequently, the nano-particles comprising of the beta-glucans and iodine was expected to be a promising drug-carrier.

壳聚糖、可得聚糖等β-葡聚糖具有有效的生理活性。然而，对于它们的β-葡聚糖的实际使用来说，存在着在中性水中不溶的显著缺点。为了开发有希望的医用纳米材料作为药物载体，其β-葡聚糖参与克服这一缺点，我们计划将其β-葡聚糖与亲水性和生物相容的聚合物、聚乙二醇和温度敏感型聚(N-异丙基丙烯酰胺)进行接枝(G)和嵌段(B)型共聚。合成了一些可溶于中性水溶液的g-型和b型共聚物，并与碘进行分子组装络合，得到了尺寸约为50-100 nm的环境友好型纳米粒子，其内部聚集态的核中含有碘。因此，由β-葡聚糖和碘组成的纳米粒子有望成为一种很有前途的药物载体。

项目成果

カーボンナノチューブ/パーフルオロアルコキシ樹脂複合塗布膜の作製とその物理化学的特性

碳纳米管/全氟烷氧基树脂复合涂膜的制备及其理化性能

• 发表时间: 2013
• 作者: 桜井僚;長岡朋弥;土屋好司;矢島博文
• 通讯作者: 矢島博文

キシログルカン-ヨウ素錯体の物理化学的特性に及ぼす側鎖効果

侧链对木葡聚糖-碘复合物理化性质的影响

• 发表时间: 2011
• 作者: 加藤晴久;矢島博文 他2名
• 通讯作者: 矢島博文 他2名

キトサン /カーボンマイクロコイル複合足場材料の作製と骨再生への機能化

壳聚糖/碳微线圈复合支架材料的制备及骨再生功能化

• 发表时间: 2013
• 作者: 坂東加奈子;青景知弘;土屋好司;陳秀琴;元島栖二;矢島博文
• 通讯作者: 矢島博文

Improvement of cell attachment capabilities of poly-l-lactic acid films by modification of surface properties with ion-beam irradiation

• DOI: 10.1016/j.surfcoat.2012.12.047
• 发表时间: 2013-03
• 期刊: Surface & Coatings Technology
• 影响因子: 5.4
• 作者: Toshiyuki Tanaka;Yoshiaki Suzuki;K. Tsuchiya;H. Yajima

High Purity and Yield Separation of Semiconducting Single-Walled Carbon Nanotubes Dispersed in Aqueous Solutions with Density Gradient Ultracentrifugation Using Mixed Dispersants of Polysaccharides and Surfactants

• DOI: 10.7567/jjap.52.035102
• 发表时间: 2013-02
• 期刊: Japanese Journal of Applied Physics
• 影响因子: 1.5
• 作者: K. Tsuchiya;K. Uchida;Yoshiya Kaminosono;Kazushi Shimizu;T. Ishii;H. Yajima