Fatty acid elongation: a novel target for prostate cancer treatment

脂肪酸延伸：前列腺癌治疗的新靶点

• 批准号: nhmrc : 1138648
• 金额: $ 21.82万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fatty-acid-elongation-cancer-treatment/1318819
• 关键词: Fatty; acid; elongation; novel; target

Lipids are a class of molecules that make up cell membranes and are an important source of energy for cells. Changes in lipids occur during prostate cancer progression, most prominently in a process called fatty acid elongation, which requires enzymes called elongases. This project will seek to better understand the consequences of lipid elongation in prostate cancer cells, its potential role in therapy resistance, and whether the elongase enzymes can be targeted as new therapies.

脂质是构成细胞膜的一类分子，是细胞能量的重要来源。脂质的变化发生在前列腺癌进展期间，最突出的是在称为脂肪酸延伸的过程中，这需要称为延伸酶的酶。该项目将寻求更好地了解前列腺癌细胞中脂质延长的后果，其在治疗抗性中的潜在作用，以及延长酶是否可以作为新疗法的靶向。