Compare and contrast effects of allergen exposure via skin and airway epithelial barriers on exosome production and subsequent immune responses

比较和对比通过皮肤和气道上皮屏障接触过敏原对外泌体产生和随后免疫反应的影响

• 批准号: 2689627
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2689627
• 关键词: Compare; contrast; effects; allergen; exposure

Type I hypersensitivities, or allergic immune responses, are defined by the induction of antigen-specific Th2 cells and IgE antibody production, involving activation of the adaptive arm of the immune system during allergen exposure. Epithelial cells are one of the first lines of defence against allergen contact and epithelial cell-allergen interactions have been identified as one of the first key events in the adverse outcome pathway for allergic sensitisation and a key area of focus for future research. This PhD will examine the role of skin and airway epithelial surfaces in influencing the immune outcome after exposure to different allergens.

I 型超敏反应或过敏性免疫反应是通过诱导抗原特异性 Th2 细胞和 IgE 抗体产生来定义的，涉及在过敏原暴露期间激活免疫系统的适应性臂。上皮细胞是抵抗过敏原接触的第一道防线之一，上皮细胞与过敏原的相互作用已被确定为过敏致敏不良结果途径中的首要关键事件之一，也是未来研究的重点领域。该博士将研究皮肤和气道上皮表面在接触不同过敏原后影响免疫结果的作用。