Rapid Free-Breathing 3D High-Resolution MRI for Volumetric Liver Iron Quantification

用于体积肝铁定量的快速自由呼吸 3D 高分辨率 MRI

• 批准号: 10742197
• 负责人: Youngwook Kee
• 金额: $ 17.7万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10742197
• 关键词: 3-Dimensional; Abdomen; Address; Adult; Adverse effects; Affect; Algorithms; Anemia; Biliary; Biological Markers; Blood Transfusion; Body Image; Breathing; Cancer Patient; Cardiomyopathies; Cardiotoxicity; Caucasians; Chelating Agents; Chelation Therapy; Child; Childhood; Clinical; Clinical Management; Clinical Research; Cone; Contrast Media; Data; Development; Diagnosis; Dimensions; Directories; Endocrine; Ethnic Origin; Failure; Ferritin; Functional disorder; Genetic; Goals; Growth; Head; Hematologic Neoplasms; Hematological Disease; Hemochromatosis; Hemosiderosis; Hepatic; Hepatology; Hereditary hemochromatosis; Image; Image Analysis; Image Compression; Impairment; Individual; Inferior; Ionizing radiation; Iron; Iron Overload; Left; Liver; Liver Fibrosis; Macrophage; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Methodology; Methods; Microscopic; Modeling; Monitor; Morbidity - disease rate; Motion; Motivation; Movement; Not Hispanic or Latino; Organ; Outcome; Pancreas; Patients; Performance; Physicians; Population; Primary carcinoma of the liver cells; Process; Race; Reader; Relaxation; Research; Resolution; Risk; Sampling; Scanning; Scheme; Signal Transduction; Slice; Sorting; Speed; Structure; Techniques; Testing; Thick; Time; Tissues; Transfusion; United States; Venous blood sampling; Wait Time; Work; accurate diagnosis; body system; chelation; chronic liver disease; cluster computing; data acquisition; data space; design; efficacy evaluation; experience; high dimensionality; image reconstruction; imaging biomarker; improved; innovation; intravenous administration; iron oxide nanoparticle; liver biopsy; liver imaging; magnetic field; multidisciplinary; negative affect; novel; pediatric patients; pharmacologic; quantitative imaging; radiologist; reconstruction; research clinical testing; respiratory; side effect; spatiotemporal; standard of care; superparamagnetism; tissue oxygenation

Project Summary Motivation: In the United States, approximately 1 in 300 non-Hispanic Caucasians have hereditary hemochromatosis with varying rates in other ethnicities and races. Transfusion hemosiderosis often develops in cancer patients who have received repeated blood transfusions for cancer-related anemia treatment. Iron overload, if left untreated, can cause fatal organ damage. Treatment of iron overload aims at reducing body iron stores with phlebotomy or chelation therapy to maintain sufficiently low body iron levels while minimizing adverse effects. Liver iron concentration is widely accepted for the best indicator of total body iron stores; therefore, accurate liver iron quantification improves clinical management of iron overload and minimizes side effects of chelator administration. MRI-based R2* relaxometry (R2*-MRI) is a noninvasive clinical standard for liver iron quantification with no ionizing radiation due to its sensitivity to the presence of tissue iron. R2*-MRI acquires images at multiple time points to estimate R2* (= 1/T2*) relaxation rates at each voxel. However, clinically available R2*-MRI is prone to patient movement such as respiratory motion that breath-holding is commonly practiced during scan. Breath-holding is challenging for children and some adults, and unsatisfactory breath- holding leads to poor R2* values. The other challenge with the current R2*-MRI is caused by signal loss due to rapid T2* decay in the presence of a high concentration of iron. Severe iron loading is commonly seen in patients with transfusion-induced iron overload, and the current R2*-MRI does not reliably capture such a rapid signal decay, resulting in inaccuracy in R2* measurements. This project addresses these challenges to provide novel R2*-MRI methods for accurate and consistent liver iron quantification. Approach: The project has two development aims that are validated on clinical studies. Aim 1 will enable rapid free-breathing ultrashort TE MRI, which acquires images at multiple time points for R2* measurements. Such acquisition is achieved by incorporating a 3D center-out k-space trajectory with multiple data readouts with self- navigator without scan time overhead, facilitating parallel imaging compressed sensing. Aim 2 will enable retrospectively motion-corrected image reconstruction that makes use of a low-rank tensor structure of the acquired 3D spatiotemporal volumetric data. We will develop strategies for data parallelism and distributed computing for computationally demanding tensor-based multidimensional reconstruction. Aim 3 will determine the performance of the innovations in a clinical setting. Significance: This work will lead to rapid, robust, free-breathing abdominal MRI for more accurate assessment of liver iron overload in children and adults. The techniques will facilitate widespread application in quantitative body imaging.

项目摘要 动机：在美国，大约有300个非西班牙裔高加索人具有世袭 其他种族和种族中的血色素症和变化率的变化。输血屈血病经常在 接受癌症相关贫血治疗的反复输血的癌症患者。铁 如果未经治疗，超负荷会造成致命的器官损害。铁超负荷的治疗目的旨在减少人体铁 进行静脉切开术或螯合疗法的存储，以保持足够低的体铁水平，同时最大程度地减少不良状态 效果。肝铁浓度被广泛接受，以最佳指标的总体铁储存。所以， 准确的肝铁量化改善了铁超负荷的临床管理，并最大程度地减少了 螯合剂给药。基于MRI的R2*松弛计（R2* -MRI）是肝铁的无创临床标准 由于其对组织铁的敏感性而无电离辐射的定量。 R2*-MRI获取 在多个时间点的图像估计R2*（= 1/T2*）在每个体素处的松弛率。但是，在临床上 可用的R2*-MRI容易出现患者运动，例如呼吸运动，通常是呼吸 在扫描过程中练习。对于儿童和一些成年人而言，呼吸困难是具有挑战性的，呼吸不令人满意 - 持有导致R2*值差。当前R2*-MRI的另一个挑战是由信号损失引起的 在高浓度铁的情况下，快速T2*衰变。患者通常会看到严重的铁负荷 输血引起的铁超载，并且电流R2*-MRI不会可靠地捕获如此迅速的信号 衰减，导致R2*测量结果不准确。该项目解决了这些挑战以提供新颖的挑战 R2*-MRI方法，用于准确且一致的肝铁定量。 方法：该项目具有两个在临床研究中验证的开发目标。 AIM 1将使快速 自由呼吸的Ultrashort TE MRI，该MRI在多个时间点获取R2*测量值的图像。这样的 通过将3D中心的K空间轨迹与多个数据读数结合在一起，可以实现获取 导航器没有扫描时间开销，促进平行成像压缩感应。 AIM 2将启用 回顾性运动校正图像重建，利用低级张量结构 获得的3D时空容量数据。我们将制定数据并行性的策略并分发 计算基于张量的多维重建的计算。 AIM 3将确定 创新在临床环境中的表现。 意义：这项工作将导致快速，健壮，自由呼吸的腹部MRI，以进行更准确的评估 儿童和成人的肝脏铁超负荷。这些技术将有助于广泛的定量应用 身体成像。