Rapid Free-Breathing 3D High-Resolution MRI for Volumetric Liver Iron Quantification

用于体积肝铁定量的快速自由呼吸 3D 高分辨率 MRI

• 批准号: 10742197
• 负责人: Youngwook Kee
• 金额: $ 17.7万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10742197
• 关键词: 3-Dimensional; Abdomen; Address; Adult; Adverse effects; Affect; Algorithms; Anemia; Biliary; Biological Markers; Blood Transfusion; Body Image; Breathing; Cancer Patient; Cardiomyopathies; Cardiotoxicity; Caucasians; Chelating Agents; Chelation Therapy; Child; Childhood; Clinical; Clinical Management; Clinical Research; Cone; Contrast Media; Data; Development; Diagnosis; Dimensions; Directories; Endocrine; Ethnic Origin; Failure; Ferritin; Functional disorder; Genetic; Goals; Growth; Head; Hematologic Neoplasms; Hematological Disease; Hemochromatosis; Hemosiderosis; Hepatic; Hepatology; Hereditary hemochromatosis; Image; Image Analysis; Image Compression; Impairment; Individual; Inferior; Ionizing radiation; Iron; Iron Overload; Left; Liver; Liver Fibrosis; Macrophage; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Methodology; Methods; Microscopic; Modeling; Monitor; Morbidity - disease rate; Motion; Motivation; Movement; Not Hispanic or Latino; Organ; Outcome; Pancreas; Patients; Performance; Physicians; Population; Primary carcinoma of the liver cells; Process; Race; Reader; Relaxation; Research; Resolution; Risk; Sampling; Scanning; Scheme; Signal Transduction; Slice; Sorting; Speed; Structure; Techniques; Testing; Thick; Time; Tissues; Transfusion; United States; Venous blood sampling; Wait Time; Work; accurate diagnosis; body system; chelation; chronic liver disease; cluster computing; data acquisition; data space; design; efficacy evaluation; experience; high dimensionality; image reconstruction; imaging biomarker; improved; innovation; intravenous administration; iron oxide nanoparticle; liver biopsy; liver imaging; magnetic field; multidisciplinary; negative affect; novel; pediatric patients; pharmacologic; quantitative imaging; radiologist; reconstruction; research clinical testing; respiratory; side effect; spatiotemporal; standard of care; superparamagnetism; tissue oxygenation

Project Summary Motivation: In the United States, approximately 1 in 300 non-Hispanic Caucasians have hereditary hemochromatosis with varying rates in other ethnicities and races. Transfusion hemosiderosis often develops in cancer patients who have received repeated blood transfusions for cancer-related anemia treatment. Iron overload, if left untreated, can cause fatal organ damage. Treatment of iron overload aims at reducing body iron stores with phlebotomy or chelation therapy to maintain sufficiently low body iron levels while minimizing adverse effects. Liver iron concentration is widely accepted for the best indicator of total body iron stores; therefore, accurate liver iron quantification improves clinical management of iron overload and minimizes side effects of chelator administration. MRI-based R2* relaxometry (R2*-MRI) is a noninvasive clinical standard for liver iron quantification with no ionizing radiation due to its sensitivity to the presence of tissue iron. R2*-MRI acquires images at multiple time points to estimate R2* (= 1/T2*) relaxation rates at each voxel. However, clinically available R2*-MRI is prone to patient movement such as respiratory motion that breath-holding is commonly practiced during scan. Breath-holding is challenging for children and some adults, and unsatisfactory breath- holding leads to poor R2* values. The other challenge with the current R2*-MRI is caused by signal loss due to rapid T2* decay in the presence of a high concentration of iron. Severe iron loading is commonly seen in patients with transfusion-induced iron overload, and the current R2*-MRI does not reliably capture such a rapid signal decay, resulting in inaccuracy in R2* measurements. This project addresses these challenges to provide novel R2*-MRI methods for accurate and consistent liver iron quantification. Approach: The project has two development aims that are validated on clinical studies. Aim 1 will enable rapid free-breathing ultrashort TE MRI, which acquires images at multiple time points for R2* measurements. Such acquisition is achieved by incorporating a 3D center-out k-space trajectory with multiple data readouts with self- navigator without scan time overhead, facilitating parallel imaging compressed sensing. Aim 2 will enable retrospectively motion-corrected image reconstruction that makes use of a low-rank tensor structure of the acquired 3D spatiotemporal volumetric data. We will develop strategies for data parallelism and distributed computing for computationally demanding tensor-based multidimensional reconstruction. Aim 3 will determine the performance of the innovations in a clinical setting. Significance: This work will lead to rapid, robust, free-breathing abdominal MRI for more accurate assessment of liver iron overload in children and adults. The techniques will facilitate widespread application in quantitative body imaging.

项目摘要 动机：在美国，大约每300名非西班牙裔白人中就有1名患有遗传性 在其他种族和人种中有不同的发病率。输血性含铁血黄素沉着症常发生于 接受过重复输血以治疗癌症相关贫血的癌症患者。铁 如果不及时治疗，超负荷会导致致命的器官损伤。治疗铁超载的目的是减少体内铁 储存静脉切开术或螯合疗法，以维持足够低的体内铁水平，同时最大限度地减少不良反应。 方面的影响.肝脏铁浓度被广泛接受为全身铁储存的最佳指标;因此， 准确的肝脏铁定量改善了铁过载的临床管理，并最大限度地减少了 螯合剂施用。基于MRI的R2* 弛豫测定法（R2*-MRI）是一种无创性的肝铁临床标准 由于其对组织铁的存在的敏感性，在没有电离辐射的情况下进行定量。R2*-MRI采集 多个时间点的图像以估计每个体素的R2*（= 1/T2*）弛豫率。然而，临床上 可用的R2*-MRI易于患者移动，例如呼吸运动， 在扫描过程中练习。屏气对儿童和一些成年人来说是具有挑战性的，而不满意的呼吸- 保持导致差的R2* 值。当前R2*-MRI的另一个挑战是由信号丢失引起的， 在高浓度铁存在下T2* 快速衰减。严重的铁负荷常见于患者 由于输血引起的铁过载，目前的R2*-MRI不能可靠地捕获这种快速信号 衰减，导致R2* 测量不准确。该项目解决了这些挑战，以提供新颖的 R2*-MRI方法用于准确和一致的肝脏铁定量。 方法：该项目有两个开发目标，并在临床研究中得到验证。目标1将使快速 自由呼吸超短TE MRI，在多个时间点采集图像进行R2* 测量。等 通过将3D中心向外k空间轨迹与多个数据读出结合， 导航器没有扫描时间开销，便于并行成像压缩感知。目标2将使 回顾性运动校正的图像重建，其利用图像的低秩张量结构， 采集三维时空体数据。我们将开发数据并行和分布式的策略， 计算要求高的基于张量的多维重建。目标3将决定 在临床环境中的创新表现。 意义：这项工作将导致快速，强大，自由呼吸腹部MRI更准确的评估 儿童和成人肝脏铁超负荷。该技术将促进定量分析的广泛应用。 身体成像