Cortical Hyperexcitability Underlies Aberrant Auditory Perception

皮质过度兴奋是听觉感知异常的基础

• 批准号: 2700691
• 金额: --
• 依托单位: Lancaster University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2700691
• 关键词: Cortical; Hyperexcitability; Underlies; Aberrant; Auditory

Aberrant perceptual experiences are associated with underlying excitation of neural activity known as cortical hyperexcitability (CH; Wilkins, 1995). Resulting percepts are cytoarchitecturally specific, that is the perceptual domain is dependent on the cortical region of hyperexcitability (Burke, 2002). These aberrations and underlying CH are characteristic of several disorders and psychopathologies such as Migraine with Aura (MwA) and Schizophrenia (Palmer et al., 2000; Spencer et al., 2009). MwA patients are known to have a hyperexcitable visual cortex (Mulleners et al., 2001). Using TMS we know phosphene thresholds, the intensity of magnetic stimulation required to induce illusory phosphenes, is lower in MwA patients than controls (Aurora et al., 2003). BOLD response data suggests MwA patients experience significantly elevated V1 activity time-locked to aberrant visual migraine symptoms (Hadjikhani et al., 2001). This suggests visual symptoms of migraine are intrinsically linked to underlying CH.As such, Wilkins (1995) presented a series of grating patterns of high, medium, and low frequency to MwA patients and collected data on the visual distortions (pattern glare) elicited, thus creating the pattern glare test. MwA patients consistently show greater susceptibility to pattern glare than control participants (Evans & Stevenson, 2008). Neuroimaging studies suggest the most distressing patterns produce short, high amplitude Bloody Oxygen Level Dependent (BOLD) responses in the visual cortex (Haigh, Cooper & Wilkins, 2015). Such responses are associated with lower GABA concentrations, a proposed modulator for localised CH (Muthukurmaraswamy et al., 2012).

异常感知体验与被称为皮质过度兴奋的神经活动的潜在兴奋相关（CH; Wilkins，1995）。由此产生的感知是细胞结构特异性的，即感知域依赖于过度兴奋的皮层区域（Burke，2002）。这些畸变和潜在的CH是几种疾病和精神病理学的特征，例如先兆偏头痛（MwA）和精神分裂症（Palmer等人，2000; Spencer等人，2009年）。已知MwA患者具有过度兴奋的视觉皮层（Mulleners等人，2001年）。使用TMS，我们知道光幻视阈值，即诱导错觉光幻视所需的磁刺激强度，在MwA患者中低于对照组（Aurora等人，2003年）。BOLD响应数据表明MwA患者经历显著升高的V1活动，其时间锁定于异常视觉偏头痛症状（Hadjikhani等人，2001年）。这表明偏头痛的视觉症状与潜在的CH有内在联系。因此，Wilkins（1995）向MwA患者提供了一系列高、中、低频率的光栅图案，并收集了引起的视觉失真（图案眩光）的数据，从而创建了图案眩光测试。MwA患者始终比对照参与者显示出对模式眩光的更大易感性（Evans &史蒂文森，2008）。神经影像学研究表明，最令人痛苦的模式在视觉皮层中产生短，高振幅的血氧水平依赖（BOLD）反应（黑格，库珀和威尔金斯，2015）。这种反应与较低的GABA浓度有关，GABA是一种针对局部CH的建议调节剂（Muthukurmaraswamy等人，2012年）。