Fundamental Aspects of the Delivery of Peptide Therapeutics

该项目旨在详细了解多肽通过胃肠道粘液和上皮渗透性差的原因，从而开发一种自相互作用色谱技术，通过计算第二维里系数的变化，可用于测量各种多肽的相互作用及其相关的传递机制。这种色谱技术的潜力不在于完美地模仿肽在上皮层中的渗透性，而在于在研究过程中充当高通量的第一阶段过滤器，这将与更昂贵、更慢的体外/体内技术相辅相成，并减少其数量。

This project aims to understand in detail the causes of the poor permeability of peptides through GI tract mucus and the epithelial layer and thereby, develop a self-interaction chromatographic technique that may be used to measure the interactions of various peptides and their associated delivery mechanisms, by calculating the change in second virial coefficient. The potential for this chromatographic technique is not to imitate peptide permeability in the epithelial layer perfectly but to act as a high-throughput, first-stage filter in the research process, which will be complemented by and reduce the number of the more expensive and slower in-vitro/in-vivo techniques.