Fundamental Aspects of the Delivery of Peptide Therapeutics

本项目旨在详细了解多肽通过胃肠道粘液和上皮层的渗透性差的原因，从而开发一种自相互作用色谱技术，该技术可用于通过计算第二维里系数的变化来测量各种多肽及其相关递送机制的相互作用。这种色谱技术的潜力是不模仿肽的渗透性在上皮层完美，但作为一个高通量，在研究过程中的第一阶段过滤器，这将是补充，并减少了更昂贵和更慢的体外/体内技术的数量。

This project aims to understand in detail the causes of the poor permeability of peptides through GI tract mucus and the epithelial layer and thereby, develop a self-interaction chromatographic technique that may be used to measure the interactions of various peptides and their associated delivery mechanisms, by calculating the change in second virial coefficient. The potential for this chromatographic technique is not to imitate peptide permeability in the epithelial layer perfectly but to act as a high-throughput, first-stage filter in the research process, which will be complemented by and reduce the number of the more expensive and slower in-vitro/in-vivo techniques.