Targeting bacterial membrane proteins for new antimicrobial strategies

针对细菌膜蛋白的新抗菌策略

• 批准号: 2717199
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2717199
• 关键词: Targeting; bacterial; membrane; proteins; new

Bacterial antibiotic resistance is a global health challenge in both public health and biodefence but new antibiotic development by large pharma is in decline. The void in the sector is being filled by academic and biotech companies leading to the development of new therapeutic technologies that can provide new safe and effective antibiotics. We will collaborate with Dstl to investigate the membrane protein complexes responsible for cell wall biosynthesis in selected pathogens using a variety of new approaches. We will focus on the assembly of the bacterial cell wall, a validated target for existing antibiotics where novel insight in the past decade from mechanistic studies and advances in bacterial cell biology, have provided new opportunity and understanding related to this process offering fresh perspectives in new antibiotic discovery. www.warwick.ac.uk/go/ropergroup

细菌抗生素耐药性是公共卫生和生物防御领域的全球健康挑战，但大型制药公司的新抗生素开发正在下降。该领域的空白正在由学术和生物技术公司填补，从而导致新的治疗技术的开发，可以提供新的安全有效的抗生素。我们将与Dstl合作，使用各种新方法研究选定病原体中负责细胞壁生物合成的膜蛋白复合物。我们将专注于细菌细胞壁的组装，这是现有抗生素的一个经过验证的目标，在过去十年中，从细菌细胞生物学的机制研究和进展中获得的新见解提供了与此过程相关的新机会和理解，为新抗生素发现提供了新的视角。www.warwick.ac.uk/go/ropergroup