Fetal sex: an important determinant of the placental transcriptome

胎儿性别：胎盘转录组的重要决定因素

• 批准号: nhmrc : 1059120
• 负责人: A/Pr Cheryl Shoubridge
• 金额: $ 36.91万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fetal-sex-an-placental-transcriptome/454731
• 关键词: Fetal; sex; important; determinant; placental

There are fetal sex differences in pregnancy outcomes that place boys at greater risk than girls. These are likely caused by genetic differences in the placenta. We will use 21st century gene sequencing technology to obtain the complete sequence of placental genes in early pregnancy and normal term placenta to determine what the genetic differences are between male and female placentas. This may be important in developing future sex specific therapeutics for babies in the neonatal nursery.

妊娠结局中存在胎儿性别差异，使男孩面临比女孩更大的风险。这很可能是由于胎盘的遗传差异造成的。我们将利用21世纪的基因测序技术获得早孕和正常足月胎盘的完整胎盘基因序列，以确定男性和女性胎盘之间的遗传差异。这在未来为新生儿托儿所的婴儿开发性别特异性治疗方法方面可能很重要。