Overhauser Enhanced Magnetic Resonance Imaging (OMRI)

奥豪瑟增强磁共振成像 (OMRI)

• 批准号: 7057532
• 负责人: Michael Lee
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7057532
• 关键词: bioimaging /biomedical imaging; cell line; contrast media; neoplastic cell; nuclear magnetic resonance spectroscopy; perfusion; technology /technique development

Project 2: Overhauser enhanced Magnetic Resonance Imaging. (OMRI)We have examined several tumor models in mice to evaluate the image enhancement profiles. Different tumor types were grown in mice and OMRI experiments were carried out using Oxo 63 as the contrast agent when tumors were at the size of 1 ml. Enhancement profiles were found to be significantly varied in the tumors examined. The melanoma cell line B16 exhibited the highest enhancement where as the SCC cell line (squamous cell carcinoma) exhibited the least enhancement. Other cell lines such as the RIF-1, HT-29 exhibited intermediate enhancement. Additional experiments with conventional contrast enhanced MRI using Gd3+-DTPA on these animals with different tumors showed time -intensity profiles in images which had different behavior in each tumor type tested. Histologic studies quantitating the microvessel density in tumors are proposed to be carried out to study the dependence of image enhancement vs tumor perfusion.

项目二：检修用户增强磁共振成像。我们检查了几种小鼠肿瘤模型来评估图像增强特性。不同类型的肿瘤在小鼠体内生长，当肿瘤大小为1ml时，使用Oxo 63作为造影剂进行OMRI实验，发现在所检查的肿瘤中增强谱有显着变化。黑色素瘤细胞系B16表现出最高的增强，而鳞状细胞癌细胞系（鳞状细胞癌）表现出最低的增强。其他细胞系如RIF-1、HT-29表现出中等程度的增强。在这些不同肿瘤的动物上使用Gd3+-DTPA进行常规对比增强MRI的其他实验显示，在每种肿瘤类型中具有不同行为的图像中的时间强度谱。为了研究图像增强对肿瘤灌注的依赖性，提出了定量肿瘤微血管密度的组织学研究。