Continuous Wave Electron Paramagnetic Resonance Imaging

项目三：连续波电子顺磁共振成像。该技术使用氧化还原敏感的顺磁造影剂（称为氮氧化物）对组织/肿瘤氧化还原状态进行无创评估。我们现在正在研究作为氧化应激报告者的新分子，这些分子是氮氧化物的前体，通过与活性氧的氧化转化为相应的氮氧化物。这种氧化应该提供组织氧化应激的信息。仪器也正在开发中，以提供更高频率的检测，以提高灵敏度和空间分辨率。

Project 3: Continuous Wave Electron Paramagnetic Resonance Imaging.This technique provides non-invasive assessment of tissue/tumor redox status using redox sensitive paramagnetic contrast agents called nitroxides. We have now examining new molecules as reporters of oxidative stress, which are precursors of nitroxides and are converted to the corresponding nitroxide by oxidation with reactive oxygen species. Such oxidation should provide information on tissue oxidative stress. Instrumentation is also being developed to provide detection at higher frequencies to give enhanced sensitivity and spatial resolution.