The role of La and Related Protein family in ribosome biogenesis

La及相关蛋白家族在核糖体生物合成中的作用

• 批准号: 2723231
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2723231
• 关键词: role; La; Related; Protein; family

The La-related protein - LARP- superfamily constitute an evolutionary conserved group ofRNA Binding Proteins - RBPs. Humans contain seven LARP paralogues, a number of whichhave been shown to control ribosome biogenesis, a central process in every living cell. It ishowever unclear whether this is a conserved feature of all LARPs and the extent of theirfunctional and mechanistic overlap remains to be understood. The aim of this project is tosystematically assess the impact of each human LARP paralogue towards regulation ofribosome biogenesis, as well as revealing the molecular mechanisms of this regulation. Thisinterdisciplinary work will be conducted using integrated structural, biochemical, multi-omics,and cellular approaches,taking advantage of the complementary expertise of the twosupervisors.

La相关蛋白（LARP）超家族是RNA结合蛋白（RBP）中进化保守的一个家族。人类有七个LARP旁系同源物，其中一些已经被证明控制核糖体生物合成，这是每个活细胞的中心过程。目前尚不清楚这是否是所有LARP的保守特征，其功能和机制重叠的程度仍有待了解。本项目的目的是系统地评估每个人LARP对核糖体生物合成的调控作用，并揭示这种调控的分子机制。这一跨学科的工作将使用综合的结构，生物化学，多组学和细胞的方法进行，利用互补的专业知识的两个主管。