The role of La and Related Protein family in ribosome biogenesis

La相关蛋白-LARP-超家族构成了一组进化保守的RNA结合蛋白-RBPs。人类含有七个LARP类似物，其中一些已被证明控制核糖体的生物发生，这是每个活细胞的一个中心过程。目前尚不清楚这是否是所有LARP的保守特征，它们在功能和机制上的重叠程度仍有待了解。本项目的目的是系统地评估每个人类LARP类似物对核糖体生物发生调控的影响，并揭示这种调控的分子机制。这项跨学科的工作将使用综合的结构、生化、多组学和细胞方法进行，利用两位监督者的互补专业知识。

The La-related protein - LARP- superfamily constitute an evolutionary conserved group ofRNA Binding Proteins - RBPs. Humans contain seven LARP paralogues, a number of whichhave been shown to control ribosome biogenesis, a central process in every living cell. It ishowever unclear whether this is a conserved feature of all LARPs and the extent of theirfunctional and mechanistic overlap remains to be understood. The aim of this project is tosystematically assess the impact of each human LARP paralogue towards regulation ofribosome biogenesis, as well as revealing the molecular mechanisms of this regulation. Thisinterdisciplinary work will be conducted using integrated structural, biochemical, multi-omics,and cellular approaches,taking advantage of the complementary expertise of the twosupervisors.