Phase behaviour and disruption in model bacterial cell envelopes

模型细菌细胞包膜的相行为和破坏

• 批准号: 2726743
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2726743
• 关键词: Phase; behaviour; disruption; model; bacterial

Gram-negative bacteria are a major health threat due to their rapidly increasing resistance to antibiotics. A key aspect of this resistance is the protective outer membrane that surrounds these bacteria. Scientifically, this outer membrane is interesting because of the different soft matter states it may represent. Technically, however, it is challenging to investigate the outer membrane at the relevant molecular length scales. In this project, we will overcome this challenge by developing and characterising model systems with which we can vary and study multiple aspects of this outer membrane. These model systems can next be used as a testbed for next-generation antibiotics.

革兰氏阴性菌是一个主要的健康威胁，因为它们对抗生素的耐药性迅速增加。这种抵抗力的一个关键方面是围绕这些细菌的保护性外膜。科学上，这个外膜很有趣，因为它可能代表不同的软物质状态。然而，从技术上讲，在相关的分子长度尺度上研究外膜是具有挑战性的。在这个项目中，我们将通过开发和表征模型系统来克服这一挑战，我们可以改变和研究这个外膜的多个方面。这些模型系统接下来可以用作下一代抗生素的试验平台。