Sexual dimorphism in body fat regulation

体脂调节中的性别二态性

• 批准号: 7114568
• 负责人: Haifei Shi
• 金额: $ 4.88万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114568
• 关键词: adipose tissue; bioenergetics; biological signal transduction; body composition; body physical characteristic; eating; gender difference; gene expression; genetic manipulation; hormone regulation /control mechanism; hypothalamus; laboratory mouse; melanins; nutrition related tag; obesity; pathologic process; pituitary hormones; postdoctoral investigator; proopiomelanocortin

DESCRIPTION (provided by applicant): The prevalence of obesity with its associated co-morbidities is rapidly reaching epidemic proportions. Males and females maintain distinctive fat distribution patterns. Males tend to accumulate more visceral fat whereas females have more subcutaneous fat. The phenomenon of maintaining typical fat distributions suggests sex-specific mechanisms of body fat regulation. While females decrease energy expenditure to conserve energy during caloric restriction or after fat removal, males exhibit hyperphagia to restore fat. Our lab has found that syndecan-3-deficient mice resist diet-induced obesity and show improved glucose tolerance, the result of decreased caloric intake in males whereas increased energy expenditure in females. Mice with targeted disruption of the gene encoding granulocyte macrophage-colony stimulating factor gain fat. Males show increased caloric intake while females show reduced energy expenditure. These data suggest that males and females use distinct strategies to regulate energy balance. The overall goal for this proposal is to test specific hypotheses about the mechanistic differences between males and females that result in different body-fat accumulation and different strategies by which that body fat is defended.

描述（由申请方提供）：肥胖及其相关合并症的患病率正迅速达到流行病的比例。男性和女性保持独特的脂肪分布模式。男性往往积累更多的内脏脂肪，而女性有更多的皮下脂肪。保持典型的脂肪分布的现象表明，性别特异性的体脂调节机制。而女性减少能量消耗，以保存能量期间热量限制或脂肪去除后，男性表现出暴食，以恢复脂肪。我们的实验室发现，syndecan-3缺陷小鼠抵抗饮食诱导的肥胖，并显示出改善的葡萄糖耐量，这是雄性热量摄入减少而雌性能量消耗增加的结果。有针对性地破坏编码粒细胞巨噬细胞集落刺激因子的基因的小鼠增加脂肪。男性的热量摄入增加，而女性的能量消耗减少。这些数据表明，男性和女性使用不同的策略来调节能量平衡。这项建议的总体目标是测试有关男性和女性之间的机械差异的具体假设，这些差异导致不同的体脂积累和不同的体脂防御策略。