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Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats

脑源性神经营养因子在雄性和雌性大鼠中的中枢作用

基本信息

批准号：
8956737
负责人：
Haifei Shi
金额：
$ 39.02万
依托单位：
MIAMI UNIVERSITY OXFORD
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-25 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8956737
关键词：
Adipose tissue Agreement Anabolism Area Authorship Biological Body Temperature Body Weight Brain Brain-Derived Neurotrophic Factor Brown Fat Cardiovascular Diseases Cell Nucleus Coupled Data Dose Endocrine Energy Metabolism Environment FOS gene Female Gender Goals Health Homeostasis Hormones Human Immediate-Early Genes Immunohistochemistry Incidence Individual Injection of therapeutic agent Intervention Label Laboratory Rat Learning Maps Measures Mentors Messenger RNA Metabolic Metabolic Diseases Metabolism Methodology Mission Molecular Muscle Neuraxis Neurons Neuropeptides Neurosecretory Systems Non-Insulin-Dependent Diabetes Mellitus Norepinephrine Obesity Overweight Pattern Peripheral Phosphotransferases Physical activity Play Population Prevalence Prevention Prevention strategy Proteins Publications Rattus Regulation Research Reverse Transcriptase Polymerase Chain Reaction Role Sex Characteristics Signal Transduction Site Skeletal Muscle Students Suid Herpesvirus 1 Surrogate Markers Sympathectomy Sympathetic Nervous System System Techniques Testing Therapeutic Thermogenesis Tissues Training Transgenic Mice Tropomyosin Tyrosine Hydroxylase Inhibitor Universities Ursidae Family Work base cancer type energy balance glucose uptake graduate student male metabolic rate molecular marker mouse model neural circuit neurochemistry neuromechanism neurotrophic factor novel therapeutics obesity prevention obesity treatment prevent programs public health relevance receptor relating to nervous system research study respiratory response sex therapeutic target undergraduate student

项目摘要

DESCRIPTION (provided by applicant): Obesity is a major health problem worldwide. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays essential roles in the regulation of energy balance in many species including humans. Thus, BDNF system could be one of the therapeutic targets for prevention and treatment of obesity. There is increasing evidence that regulation of energy balance and metabolism is not the same for both genders. Previous studies suggest that BDNF activates sympathetic nervous system to regulate metabolism. However, the exact neural circuit responsible for BDNF-induced energy metabolism is unknown. Additionally, females are more sensitive to BDNF's effects on the regulation of energy balance than males. The underlying neural mechanism for the sex differences in energy metabolism regulated by BDNF is unknown. This project will examine potential neural mechanism of BDNF system in regulating energy metabolism in male and female rats. First, the central nervous system-peripheral tissue circuit involving BDNF will be identified. Then changes in specific sympathetic molecular markers and sympathetic drive to metabolic tissues by BDNF administration will be assessed. Collectively, this project will provide direct neuroanatomical, neurofunctional, molecular, and neurochemical evidence underlying the mechanisms of BDNF's effects on metabolism and energy homeostasis. Additionally, this project will provide important new information about sex differences in response to BDNF administration. Such information is invaluable for identifying gender-specific biological targets for intervention to prevent or treat obesity. Furthermore, this project provides plentiful opportunities for graduate and undergraduate students to participate in research and to enhance research environment at Miami University, in agreement with the R15 mission.

描述（由申请人提供）：肥胖是全球范围内的主要健康问题。脑源性神经营养因子（BDNF）是一种神经营养因子，在包括人类在内的许多物种的能量平衡调节中发挥重要作用。因此，BDNF系统可能成为肥胖防治的治疗靶点之一。越来越多的证据表明，男女对能量平衡和新陈代谢的调节是不一样的。以往的研究表明BDNF激活交感神经系统调节代谢。然而，负责BDNF诱导的能量代谢的确切神经回路是未知的。此外，女性对BDNF在能量平衡调节方面的作用比男性更敏感。BDNF调节能量代谢的性别差异的潜在神经机制尚不清楚。该项目将研究脑源性神经营养因子系统调节雄性和雌性大鼠能量代谢的潜在神经机制。首先，将确定涉及BDNF的中枢神经系统-外周组织回路。然后将评估特定交感神经分子标记物的变化和BDNF给药对代谢组织的交感神经驱动。总的来说，这个项目将提供直接的神经解剖学，神经功能，分子和神经化学证据的BDNF的代谢和能量稳态的影响机制。此外，该项目将提供重要的新信息，性别差异，在响应BDNF管理。这些信息对于确定预防或治疗肥胖的干预措施的性别特异性生物靶点非常宝贵。此外，该项目提供了丰富的机会，研究生和本科生参与研究，并加强研究环境在迈阿密大学，在协议的R15使命。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Distinct metabolic effects following short-term exposure of different high-fat diets in male and female mice.

在雄性和雌性小鼠中不同高脂饮食短期暴露后，明显的代谢作用。

DOI：
10.1507/endocrj.ej13-0455
发表时间：
2014
期刊：
Endocrine journal
影响因子：
2
作者：
Senthil Kumar SP;Shen M;Spicer EG;Goudjo-Ako AJ;Stumph JD;Zhang J;Shi H
通讯作者：
Shi H

Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis.

DOI：
10.1155/2015/294278
发表时间：
2015
期刊：
International journal of endocrinology
影响因子：
2.8
作者：
Shen M;Shi H
通讯作者：
Shi H

Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels.

DOI：
10.1016/j.yhbeh.2013.01.009
发表时间：
2013-03
期刊：
HORMONES AND BEHAVIOR
影响因子：
3.5
作者：
Zhu, Zheng;Liu, Xian;Kumar, Shiva Priya Dharshan Senthil;Zhang, Jing;Shi, Haifei
通讯作者：
Shi, Haifei

Effects of energy status and diet on Bdnf expression in the ventromedial hypothalamus of male and female rats.