PROJECT ALLIFE-EXERCISE AND LEUKEMIA SURVIVORS

ALLIFE 计划 - 锻炼与白血病幸存者

• 批准号: 7126739
• 负责人: Kevin Charles Oeffinger
• 金额: $ 33.1万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7126739
• 关键词: behavior therapy; behavioral /social science research tag; body physical activity; cardiovascular disorder prevention; clinical research; disease /disorder proneness /risk; health behavior; human subject; human therapy evaluation; leukemia; lifestyle; long term survivor; outcomes research; pediatric neoplasm /cancer; physical fitness; young adult human (21-34)

DESCRIPTION (provided by applicant): Adult survivors of childhood leukemia are a growing population that have an excess in all-cause and cardiovascular (CVD)-related mortality and are at risk for multiple health problems, including CVD, osteoporosis, and obesity. Physical activity is protective and reduces risk for CVD, hypertension, Type 2 diabetes mellitus, and osteoporosis. The Lifestyle Physical Activity intervention has been efficacious in the general population in increasing sustainable levels of moderate-intensity physical activity and cardiorespiratory fitness and improving cardiovascular risk profiles and mental health. A targeted intervention tailored to the needs of leukemia survivors and intended to increase sustainable levels of moderate-intensity physical activity is not only warranted, but critical. It is imperative that methods to reduce morbidity and mortality of this young population while enhancing quality of life and productivity be addressed. The proposed study, Project ALLIFE (Acute Leukemia Lifestyle Intervention For Everyday), is a 12- month effectiveness trial with 120 young adult survivors of childhood leukemia randomized to either the Lifestyle Physical Activity intervention (ALLIFE-I) or a standard control group who will receive a periodic generic health newsletter (ALLIFE-SC). Major data collections will be at baseline, 6- and 12-months, with the two primary outcomes being levels of physical activity, as measured by 7-day physical activity recall, and cardiorespiratory fitness, as measured by the Aerobic Adaptation Test. Secondary outcomes will include other well-established measures of physical activity, cardiovascular risk profiles, gait and balance assessment, and psychological measurements. The primary research hypothesis to be tested is that the Lifestyle intervention will significantly increase physical activity and cardiorespiratory fitness in adult survivors of childhood leukemia in comparison with standard care. Three additional questions to be addressed are: determining if such an intervention leads to improvement in cardiovascular risk profile; determining if gait and balance disturbances are related to physical inactivity in leukemia survivors and if these disturbances improve with the intervention; and identifying factors that are predictive of improvement or lack of improvement in outcomes. This study will represent the first clinical trial aimed at increasing physical activity in leukemia survivors and will advance our understanding of this vulnerable population.

描述（由申请人提供）：儿童白血病的成年幸存者是一个不断增长的人群，其全因和心血管（CVD）相关死亡率过高，并且存在多种健康问题的风险，包括CVD，骨质疏松症和肥胖。体育活动具有保护作用，可降低心血管疾病、高血压、2型糖尿病和骨质疏松症的风险。在普通人群中，生活方式体育活动干预在提高中等强度体育活动和心肺健康的可持续水平以及改善心血管风险概况和心理健康方面是有效的。针对白血病幸存者的需要进行有针对性的干预，旨在增加可持续的中等强度身体活动水平，这不仅是必要的，而且是至关重要的。必须设法降低这一年轻人口的发病率和死亡率，同时提高生活质量和生产力。拟议的研究项目ALLIFE（急性白血病日常生活方式干预）是一项为期12个月的有效性试验，120名儿童白血病的年轻成年幸存者随机分为生活方式体育活动干预组（ALLIFE- i）和标准对照组，后者将定期收到一份通用健康通讯（ALLIFE- sc）。主要数据收集将在基线，6个月和12个月，两个主要结果是身体活动水平，通过7天的身体活动回忆来测量，以及心肺健康，通过有氧适应测试来测量。次要结果将包括其他完善的身体活动测量、心血管风险概况、步态和平衡评估以及心理测量。待验证的主要研究假设是，与标准治疗相比，生活方式干预将显著增加儿童白血病成年幸存者的身体活动和心肺健康。需要解决的另外三个问题是：确定这种干预是否会改善心血管风险概况；确定白血病幸存者的步态和平衡障碍是否与缺乏运动有关，以及这些障碍是否在干预后得到改善；并确定预测结果改善或缺乏改善的因素。这项研究将是第一个旨在增加白血病幸存者身体活动的临床试验，并将促进我们对这一弱势群体的理解。