Recognition Memory after Mild Traumatic Brain Injury

轻度脑外伤后的识别记忆

• 批准号: 7157862
• 负责人: Hala J Darwish
• 金额: $ 5.05万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157862
• 关键词: behavior test; behavioral /social science research tag; brain injury; form /pattern perception; laboratory rat; memory; memory disorders; neural information processing; predoctoral investigator; sequential perception; temporal lobe /cortex; trauma; visual perception

DESCRIPTION (provided by applicant): Approximately 300,000 Americans sustain a Mild Traumatic Brain Injury (MTBI) each year. Although the injury is classified as mild, the brain is indeed injured. MTBI results in subtle neuro-anatomical and neuro- psychological deficits that may lead to disrupted lifestyle. Memory deficits, including recognition and temporal order abilities, have been reported after MTBI. We know little about the characteristics and trajectory of impaired recognition memory after MTBI. The aim of this application is to use an animal model to systematically explore recognition memory following MTBI. The intent is to characterize behaviors and examine brain tissue histologically. Such work is not yet possible in human. The exploration of the brain regions associated with recognition and temporal order memory deficits after MTBI, such as the hippocampus, the parahippocampus and the perirhinal cortex, will help determine some of the possible conditions under which behaviors resulting from recognition deficits are observed. Better understanding of recognition memory deficits after MTBI and the conditions under which they are observed will guide the development of targeted nursing therapies.

描述（由申请人提供）：每年约有300,000名美国人承受轻度创伤性脑损伤（MTBI）。尽管损伤被归类为轻度，但大脑确实受伤。 MTBI导致微妙的神经动物和神经心理缺陷可能导致生活方式中断。 MTBI之后，已经报告了记忆缺陷，包括识别和时间顺序能力。我们对MTBI后识别记忆受损的特征和轨迹一无所知。该应用的目的是使用动物模型系统地探索MTBI之后的识别记忆。目的是表征行为并在组织学上检查脑组织。这种工作在人类中是不可能的。 MTBI之后与识别和时间顺序记忆缺陷相关的大脑区域的探索，例如海马，帕拉希帕克群岛和周围皮层，将有助于确定观察到识别缺陷引起的行为的某些可能条件。更好地了解MTBI后识别记忆缺陷及其观察到的条件将指导有针对性的护理疗法的发展。