Minority Predoctoral Fellowship Program

少数族裔博士前奖学金计划

• 批准号: 7120524
• 负责人: CARLOS Ramon PONCE
• 金额: $ 3.54万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7120524
• 关键词: Macaca; behavior test; behavioral /social science research tag; brain mapping; hypothermia; motion perception; neural information processing; predoctoral investigator; visual cortex; visual perception

DESCRIPTION (provided by applicant): A fundamental feature of the mammalian visual system is its decomposition of the visual image into specialized streams of information, some dedicated to processing motion, others to object shape or color. Although these channels have been well-defined from their origin in the retina to several regions of the visual cortex, less is known about how they are eventually re-integrated to obtain accurate interpretations of the visual world. We are currently investigating how two different motion-processing pathways in the visual cortex of the macaque (a direct V1-MT pathway and an indirect V1-V2A/3-MT pathway), combine information to obtain accurate interpretations of how objects move. We are doing this by using a reversible-inactivation technique (localized cooling) to silence neuronal activity of areas V2 and V3 in the awake behaving macaque. By recording from neurons in the motion-processing area MT and recording ocular behavior, we will identify the specific visual deficiencies that arise when the above extrastriate areas do not contribute to the analysis of motion.

描述(申请人提供)：哺乳动物视觉系统的一个基本特征是它将视觉图像分解成专门的信息流，一些专门处理运动，另一些专门处理物体的形状或颜色。虽然这些通道从它们起源于视网膜到视觉皮质的几个区域已经有了很好的定义，但关于它们最终如何重新整合以获得对视觉世界的准确解释，人们知之甚少。我们目前正在研究猕猴视觉皮质中两种不同的运动处理通路(直接的V1-MT通路和间接的V1-V2a/3-MT通路)是如何结合信息来获得物体如何运动的准确解释的。我们正在通过使用可逆失活技术(局部降温)来沉默清醒行为猕猴V2和V3区的神经元活动来做到这一点。通过记录运动处理区MT中的神经元和记录眼睛行为，我们将识别当上述纹外区对运动分析没有贡献时出现的特定视觉缺陷。