Novel Platform for Advanced MR Imaging of Animal

这项提议的最终目的是为高场磁共振动物成像和光谱学创建一个增强的演示平台。这不仅证明了建造超高场磁体的可行性，更重要的是为包括人体全身核磁共振扫描仪在内的磁体建设和工程带来了全新的技术和经济。通过使用高磁场，通过提高S/N、时间和空间分辨率，实现的应用包括功能成像、分子成像和局部光谱分析，所有这些在癌症和新陈代谢研究中都至关重要。现有的磁体只能提供适中的磁场，缺乏一系列的性能和结构特征。本方案的目的是论证使用新型内部增强超导线材技术和约束非线性优化方法进行磁体设计的可行性。 构建一种具有优越的技术和操作特性的设备，包括物理尺寸小、边缘场和成本。将采购导线、加工技术、接头和建造测试线圈，以证明该技术的能力。 此外，还将展示一套完整的磁场控制系统，包括梯度和垫片线圈，针对高速和大动态范围等非常高的在体磁场应用进行了优化。 到目前为止，这种孔内设备的优化一直是应用开发的一个主要限制。 这一过程的最终目标还将有助于将斯特恩磁力公司打造成一家具有竞争力的美国高场磁共振磁体系统制造商。

The ultimate aim of this proposal is to create an enhanced demonstration platform for high-field MR animal imaging and spectroscopy. That demonstration will not only prove the feasibility of construction of very high field magnets, but more importantly, bring a completely new technology and economics to the magnet construction and engineering, including the human whole body MRI scanners. Applications enabled by the use of high magnetic fields, through increased S/N, temporal and spatial resolution, include functional imaging, molecular imaging and localized spectroscopy, all of critical importance in cancer and metabolic research. Existing magnets offer only moderate fields and lack a series of performance and structural features. It is the goal of this proposal to demonstrate, using novel internally reinforced superconducting wire technology and constrained non-linear optimization approach magnet design methods, the feasibility of constructing a device with superior technical and operational characteristics including small physical size, fringe field and cost. Procurement of conductors, processing technology, joints and construction of test coils to demonstrate the capability of the technology, will be undertaken. In addition a complete magnetic field control system including gradients and shim coils optimized for the very high field in-vivo applications, such as high speed and large dynamic range, will be demonstrated. Optimization of such in-bore equipment has been a major limitation in applications developed to date. The ultimate goal of this process will also help to establish Stern Magnetics LLC as a competitive US manufacturer of high-field MRI magnet systems.