Novel Platform for Advanced MR Imaging of Animal

该提案的最终目的是为高场MR动物成像和光谱学创建增强的演示平台。该演示不仅证明了建造极高磁场磁体的可行性，更重要的是，为磁体建造和工程带来了全新的技术和经济性，包括人体全身MRI扫描仪。通过使用高磁场，通过增加S/N，时间和空间分辨率，实现的应用包括功能成像，分子成像和局部光谱学，所有这些在癌症和代谢研究中都至关重要。现有的磁体仅提供中等磁场，并且缺乏一系列性能和结构特征。本提案的目的是使用新型内部增强超导导线技术和约束非线性优化方法磁体设计方法，证明 构造具有包括小的物理尺寸、边缘场和成本的上级的技术和操作特性的装置。将采购导体、加工技术、接头和建造测试线圈，以证明该技术的能力。 此外，还将展示一个完整的磁场控制系统，包括针对极高场体内应用（如高速和大动态范围）进行优化的梯度和匀场线圈。 这种孔内设备的优化一直是迄今为止开发的应用中的主要限制。 这一过程的最终目标也将有助于建立斯特恩磁性有限责任公司作为一个有竞争力的美国制造商的高场MRI磁体系统。

The ultimate aim of this proposal is to create an enhanced demonstration platform for high-field MR animal imaging and spectroscopy. That demonstration will not only prove the feasibility of construction of very high field magnets, but more importantly, bring a completely new technology and economics to the magnet construction and engineering, including the human whole body MRI scanners. Applications enabled by the use of high magnetic fields, through increased S/N, temporal and spatial resolution, include functional imaging, molecular imaging and localized spectroscopy, all of critical importance in cancer and metabolic research. Existing magnets offer only moderate fields and lack a series of performance and structural features. It is the goal of this proposal to demonstrate, using novel internally reinforced superconducting wire technology and constrained non-linear optimization approach magnet design methods, the feasibility of constructing a device with superior technical and operational characteristics including small physical size, fringe field and cost. Procurement of conductors, processing technology, joints and construction of test coils to demonstrate the capability of the technology, will be undertaken. In addition a complete magnetic field control system including gradients and shim coils optimized for the very high field in-vivo applications, such as high speed and large dynamic range, will be demonstrated. Optimization of such in-bore equipment has been a major limitation in applications developed to date. The ultimate goal of this process will also help to establish Stern Magnetics LLC as a competitive US manufacturer of high-field MRI magnet systems.