Development of Novel Ion Selective Biosensors

从了解大脑的生理和病理（例如癫痫、脑癌）到人类行为监测（例如可穿戴设备），微型离子传感器的应用范围非常大。该项目的目的是开发这种基于离子选择膜功能化晶体管的传感器。我们将致力于了解这些设备的物理特性，并在灵敏度、稳定性和响应时间方面将其推向性能极限。然后，我们将使用合适的神经系统疾病模型验证它们在植入式设备中的应用。

There is a great need for miniaturised ion sensors for applications ranging from understanding physiology and pathology of the brain (e.g. in epilepsy, brain cancer) to human performance monitoring (e.g. with wearables). The aim of this project is to develop such sensors based on transistors functionalised with ion selective membranes. We will aim to understand the physics of these devices and push them to their performance limits in terms of sensitivity, stability and response time. We will then validate their use in implantable devices using suitable model of neurological disorders.