Nanoparticle Coating to Increase Biliary Stent Patency

纳米颗粒涂层可提高胆道支架的通畅性

• 批准号: 6882572
• 负责人: ANTHONY GILETTO
• 金额: $ 12.33万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882572
• 关键词: bile ducts; bile obstruction; biomaterial development /preparation; biomaterial interface interaction; blood vessel prosthesis; cytotoxicity; electrochemistry; hemolysis; implant; jaundice; medical implant science; polyethylenes; scanning electron microscopy; surface coating

DESCRIPTION (provided by applicant): Biliary stenting is a common practice to relieve the symptoms of jaundice due to an obstruction of the bile duct. In this procedure, a metal or plastic stent is placed endoscopically in the bile duct to restore bile flow and subsequently, relieve jaundice. Although these stents provide relief of symptoms for 90% of the patients who receive them, the major complication of the technique is late stent blockage, due to bacterial biofilm and biliary sludge deposition. As bacteria attach to the surface of the stent and begin to form a biofilm, the lumen inevitably becomes occluded and recurrent biliary obstruction occurs. This proposal concerns the development of a new coating for polyethylene biliary stents to improve their patency, reducing complications and numerous hospital stays for patients with obstructive jaundice. Lynntech proposes an ultrasmooth coating which will ultimately delay bacterial adhesion and the encrustation of amorphous material which leads to recurrent obstruction of the stent. The novel approach stems from Lynntech's revolutionary method for depositing nanoparticles onto metal or plastic surfaces, in this case quasicrystals onto polyethylene biliary stents. It is anticipated that the economic quasicrystal coating will improve polyethylene stent patency while retaining their desirable properties such as low cost and ease of insertion and removal, properties not inherent in most metal stents.

描述（由申请人提供）： 胆道支架置入术是缓解胆管阻塞引起的黄疸症状的常见做法。在此过程中，通过内窥镜将金属或塑料支架放置在胆管中以恢复胆汁流动，随后缓解黄疸。尽管这些支架可以缓解 90% 接受支架的患者的症状，但该技术的主要并发症是由于细菌生物膜和胆泥沉积而导致支架晚期堵塞。当细菌附着在支架表面并开始形成生物膜时，管腔不可避免地会被堵塞，并发生复发性胆道梗阻。该提案涉及开发一种用于聚乙烯胆管支架的新涂层，以提高其通畅性，减少梗阻性黄疸患者的并发症和大量住院时间。 Lynntech 提出了一种超光滑涂层，该涂层最终将延缓细菌粘附和无定形材料的结壳，从而导致支架反复阻塞。这种新颖的方法源于 Lynntech 将纳米颗粒沉积到金属或塑料表面上的革命性方法，在本例中是将纳米颗粒沉积到聚乙烯胆管支架上。预计经济的准晶涂层将改善聚乙烯支架的通畅性，同时保留其所需的特性，例如低成本和易于插入和移除，而这些特性是大多数金属支架所不具备的。