Nanoparticle Coating to Increase Biliary Stent Patency

描述(由申请人提供)： 胆道支架置入术是一种常见的治疗方法，用于缓解因胆管梗阻引起的黄疸症状。在这一过程中，金属或塑料支架被放置在内窥镜下的胆管中，以恢复胆汁流动，随后缓解黄疸。虽然这些支架为接受支架的90%的患者提供了症状缓解，但该技术的主要并发症是支架晚期堵塞，原因是细菌生物膜和胆泥沉积。当细菌附着在支架表面并开始形成生物膜时，管腔不可避免地被堵塞，反复发生胆道梗阻。这项建议涉及开发一种新的聚乙烯胆管支架涂层，以提高其通畅性，减少梗阻性黄疸患者的并发症和大量住院时间。Lynntech提出了一种超光滑涂层，它最终将推迟细菌粘连和无定形材料的结垢，从而导致支架反复阻塞。这一新方法源于Lynntech的革命性方法，即在金属或塑料表面沉积纳米颗粒，在这种情况下，准晶沉积到聚乙烯胆道支架上。预计，经济的准晶涂层将改善聚乙烯支架的通畅性，同时保持其理想的特性，如低成本和易于插入和移除，这些特性是大多数金属支架所不具备的。

DESCRIPTION (provided by applicant): Biliary stenting is a common practice to relieve the symptoms of jaundice due to an obstruction of the bile duct. In this procedure, a metal or plastic stent is placed endoscopically in the bile duct to restore bile flow and subsequently, relieve jaundice. Although these stents provide relief of symptoms for 90% of the patients who receive them, the major complication of the technique is late stent blockage, due to bacterial biofilm and biliary sludge deposition. As bacteria attach to the surface of the stent and begin to form a biofilm, the lumen inevitably becomes occluded and recurrent biliary obstruction occurs. This proposal concerns the development of a new coating for polyethylene biliary stents to improve their patency, reducing complications and numerous hospital stays for patients with obstructive jaundice. Lynntech proposes an ultrasmooth coating which will ultimately delay bacterial adhesion and the encrustation of amorphous material which leads to recurrent obstruction of the stent. The novel approach stems from Lynntech's revolutionary method for depositing nanoparticles onto metal or plastic surfaces, in this case quasicrystals onto polyethylene biliary stents. It is anticipated that the economic quasicrystal coating will improve polyethylene stent patency while retaining their desirable properties such as low cost and ease of insertion and removal, properties not inherent in most metal stents.