Safe and Effective Extraction Process for Contaminated Foods

受污染食品的安全有效的提取工艺

• 批准号: 8199246
• 负责人: ANTHONY GILETTO
• 金额: $ 14.95万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-19 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199246
• 关键词: Safe; Effective; Extraction; Process; Contaminated

DESCRIPTION (provided by applicant): Food-borne toxins such as mycotoxins and gossypol continue to impact human health in diverse ways, including negative effects on reproduction, neurological function, developmental biology, renal and respiratory function, susceptibility to infectious disease, and development of cancer. The eventual impact on human and animal health depends on the frequency and amount of either acute or chronic exposure through foods. Cottonseed could potentially provide the protein requirements of half a billion people in areas of the world where malnutrition and starvation are rampant; however, the synergistic combination of gossypol and aflatoxins in cottonseed meal are of particular concern because of the acute effects on the liver, the reproduction system, and other organ systems and the chronic impact of low-level aflatoxin exposure on development of hepatocellular carcinoma and impaired immune function. Recent outbreaks due to acute exposure of humans and dogs to aflatoxin in 2004 and 2005, respectively, have reiterated the persistence of these chemical contaminants in food and the probable broad impact of chronic exposure on cancer risk in humans. Importantly, Lynntech's approach also enables extraction without the use of hexane - a toxic and heavily regulated solvent. Lynntech has developed a solvent-based technical approach for isolation of aflatoxins from any grain or oilseed, with successes based on polarity of the toxin and the ability of the solvent to partition aflatoxin into the liquid phase. Additionally during the course of our research we discovered that this process can also be applied to the removal of toxic gossypol from cottonseed product. The industry standard solvent (hexane) does a very good job at extracting vegetable oil; however, hexane is ineffective at removing aflatoxin from the high value protein/starch fraction (meal) leaving behind 100% of the aflatoxin in the solid food and feed component. Lynntech's approach is also effective for extraction of vegetable oil from grains and oilseeds with the added benefit of removing aflatoxin from the meal. Importantly, the aflatoxin partitions into the liquid oil/solvent micelle where it can be further isolated into a non-food component and where the toxin can be aggressively detoxified using ozone gas. PUBLIC HEALTH RELEVANCE: Aflatoxins are naturally occurring carcinogens that, despite regulation in diverse foods and feedstuffs, remain a health hazard to humans and animals both in the US and worldwide. There are no practical methods to isolate and destroy these toxins in contaminated raw agricultural commodities, forcing food producers and processors to choose between blending with available clean commodities or destroying the contaminated grains or oilseeds. The proposed innovation utilizes a new two-stage process integrated within the existing global industrial infrastructure in oilseed extraction to decontaminate commodities, allowing for safe, market- competitive food fractions and reduced cancer risk.

描述（由申请方提供）：真菌毒素和棉酚等食源性毒素继续以多种方式影响人类健康，包括对生殖、神经功能、发育生物学、肾和呼吸功能、感染性疾病易感性和癌症发展的负面影响。对人类和动物健康的最终影响取决于通过食物急性或慢性接触的频率和数量。棉籽有可能为世界上营养不良和饥饿猖獗的地区的5亿人提供所需的蛋白质;然而，棉籽粕中棉酚和黄曲霉毒素的协同组合特别令人关注，因为其对肝脏，生殖系统，和其他器官系统以及低水平黄曲霉毒素暴露对肝细胞癌发展和免疫功能受损的慢性影响。2004年和2005年，由于人类和狗分别急性暴露于黄曲霉毒素，最近爆发的疫情再次表明这些化学污染物在食品中的持久性以及长期暴露对人类癌症风险的可能广泛影响。重要的是，Lynntech的方法还可以在不使用己烷（一种有毒且受到严格管制的溶剂）的情况下进行提取。Lynntech开发了一种基于溶剂的技术方法，用于从任何谷物或油料种子中分离黄曲霉毒素，成功的基础是毒素的极性和溶剂将黄曲霉毒素分配到液相中的能力。另外，在研究过程中我们发现，该工艺也可以应用于棉籽产品中有毒棉酚的去除。工业标准溶剂（己烷）在提取植物油方面做得非常好;然而，己烷在从高价值蛋白质/淀粉部分（膳食）中去除黄曲霉毒素方面是无效的，在固体食品和饲料组分中留下100%的黄曲霉毒素。Lynntech的方法也适用于从谷物和油籽中提取植物油，并具有从膳食中去除黄曲霉毒素的额外好处。重要的是，黄曲霉毒素分配到液体油/溶剂胶束中，在那里它可以进一步分离成非食品成分，并且毒素可以使用臭氧气体进行积极解毒。 公共卫生相关性：黄曲霉毒素是天然存在的致癌物质，尽管在各种食品和饲料中有规定，但在美国和世界范围内仍然对人类和动物的健康构成危害。没有切实可行的方法来隔离和销毁受污染的农产品原料中的这些毒素，迫使食品生产者和加工者选择与现有的清洁商品混合，还是销毁受污染的谷物或油籽。拟议的创新利用了一种新的两阶段工艺，该工艺集成在现有的全球油籽提取工业基础设施中，以净化商品，从而获得安全、具有市场竞争力的食品馏分，并降低癌症风险。