Antimicrobial Nanocoating

描述（由申请人提供）：这个SBIR项目的目标是开发一种抗菌纳米涂层（AMNC），以解决以下重要问题：1)通过处理手接触表面（例如门把手、栏杆和浴室装置）来预防医院感染，并改善医疗保健中使用的材料（例如留置导管、中心静脉管、假体和其他侵入性设备）的杀微生物和生物膜预防性能；2)在卫生设施维护极其困难的非理想环境（例如第三世界或战场）处理牙科和外科器械，以帮助预防感染。amnc将使用等离子体增强化学气相沉积（PECVD）工艺从气相沉积到各种表面上。开发可行的AMNC需要彻底了解以下领域：1)通过PECVD沉积含有可浸出银离子的纳米级薄膜。这些将由至少两种不同的基质聚合物（有机和无机）和一系列银含量合成，通过在PECVD工艺中包含含银前体。活性金属离子的生物利用度将通过提供这些纳米涂层的亲水性和纳米尺度的孔隙度来控制。2)建立含银PECVD膜的抗菌效果与结构和组成的关系；3) amnc抑制细菌生长和生物膜发育的具体机制的研究。通过适当选择特定的反应物气体和沉积条件，薄膜的组成、厚度和形貌都是可控的。第一阶段项目的成功将导致纳米级抗菌涂层的演示，该涂层已在大约20种顶级细菌病原体的面板上进行了测试。

DESCRIPTION (provided by applicant): The goals of this SBIR project are to develop an antimicrobial nano-coating (AMNC) in order to address these important problems: 1) prevention of nosocomial infections by treating hand contact surfaces (e.g. door knobs, railings and bathroom fixtures) and improving the microbicidal and biofilm preventative properties of materials used in medical care (e.g. indwelling catheters, central lines, prostheses and other invasive devices); and 2) treating dental and surgical instruments to help prevent infections in non-ideal settings (e.g.3rd world or battlefield) where maintenance of sanitary facilities is extremely difficult. The AMNCs will be deposited from the vapor phase using a plasma-enhanced chemical vapor deposition (PECVD) process onto a variety of surfaces. Development of a viable AMNC requires thorough understanding of the following areas: 1) Deposition of nanometer-scale films via PECVD that contain leachable silver ions. These will be synthesized with at least two different matrix polymers (organic and inorganic) and a range of silver content via inclusion of silver-containing precursors in PECVD process. The bioavailability of the active metal ions will be controlled by providing these nanocoatings with a range of hydrophilicity and nanometer scaled porosity. 2) Establishing antimicrobial effectiveness of silver-containing PECVD films as a function of structure and composition; and 3) investigation of the specific mechanisms by which AMNCs inhibit bacterial growth and biofilm development. Film composition, thickness, and morphology are all controllable by suitable choice of specific reactant gases and deposition conditions. A successful Phase I project will result in the demonstration of a nanometer-scale antimicrobial coating that has been tested on a panel of approximately 20 of the top bacterial pathogens.