Chemical biology tools to understand and modulate immune clearance of microbial infections

大多数现有的抗生素对细菌感染无效，因此迫切需要新的治疗方法。免疫系统是抵御细菌感染的第一道防线，细菌感染通过多种不同的机制杀死细菌。该项目旨在测试数千个分子，以找到那些在免疫攻击存在时只杀死细菌的分子。结合化学和生物方法确定这些分子的靶标并确定它们是如何产生这些影响的，将有助于其他人生产有针对性的治疗方法，以增强对细菌的免疫反应。

Most available antibiotics do not work against bacterial infections, therefore new treatments are urgently needed. The immune system is one of the first lines of defence against bacterial infection that kills bacteria via a multitude of different mechanisms. This project aims to test thousands of molecules to find those that only kill bacteria when in the presence of immune attack. Determining the targets of these molecules and identifying how they produce these effects using a combination of chemistry and biology methods will help others to produce targeted treatments to boost the immune response against bacteria.UKRI BBSRC Priorities - Combatting antimicrobial resistance - Food, nutrition and health