LUPOID DERMATOSIS

狼疮性皮肤病

• 批准号: 7391965
• 负责人: MARGRET L CASAL
• 金额: $ 0.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391965
• 关键词: LUPOID; DERMATOSIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An 11 moth old intact male German Short Hair Pointer presented with extremely flaky skin all over his whole body. The owner had reported that the dog had had the same appearance to his skin ever since the dog was obtained at 12 weeks of age. Despite all types of shampoos, steroids, and antibiotics, the condition remained the same. At times, the lesions on his nose and face would get worse, only to get better again, but would never resolve. On examination, the dog appeared physically healthy except for the dander covering his whole body. There were some crusty lesions on his nose and on his scrotum. Three biopsies from the forehead, thorax and lumbar region were obtained. There was hyperkeratosis and focal parakeratosis. Basal cell apoptosis was diffusely scattered throughout the tissues. There was also basal cell vacuolation and large numbers of melanophages within the dermis. There was a minimal lymphocytic infiltrate, which should he seen with lupus in dogs. However, on consultation with the dermatopathologists at the Hospital of the University of Pennsylvania, a diagnosis of lupus of the skin was confirmed. This dog was donated to the University of Pennsylvania. He is to be used for breeding to expand the colony. In the meantime, we have received three more German shorthair pointers that are affected with lupoid dermatosis, two females and one male. Both dogs are also to be used for breeding to expand the colony, All of the histopathological evaluations are being performed by Dr. Elizabeth Mauldin, a board certified veterinary dermatologist and pathologist. Dr Mauldin and I applied for and received a small grant from Novartis for therapeutic trials of oral cyclosporine (Atopica), an immune modulator thought to reduce or eliminate cellular reactions in the dermis, which appear to cause the disease. Biopsies and photographs are being taken at monthly intervals and the results will be summarized and presented to Novartis after 12 months of treatment. The results will be published after completion of the study. We have also received numerous skin biopsies and blood samples from affected dogs and their relatives for histopathology and DNA, respectively

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。一只11月龄的完整雄性德国短毛猫全身皮肤异常粗糙。狗主人报告说，自从狗在12周龄时获得以来，狗的皮肤外观一直相同。尽管使用了各种类型的洗发水、类固醇和抗生素，病情仍然没有改变。有时，他鼻子和脸上的病变会变得更糟，只会再次好转，但永远不会解决。经检查，这只狗除了全身有皮屑外，身体似乎很健康。他的鼻子和阴囊上有一些结痂的病变。从前额，胸部和腰部区域获得三个活检。存在角化过度和局灶性角化不全。基底细胞凋亡呈弥漫性分布。真皮内还存在基底细胞空泡化和大量噬黑素细胞。有极轻微的淋巴细胞浸润，这应该在狗的狼疮中看到。然而，在与宾夕法尼亚大学医院的皮肤病理学家协商后，确认了皮肤狼疮的诊断。这只狗被捐赠给宾夕法尼亚大学。他将被用来繁殖以扩大殖民地。与此同时，我们又收到了三只患有狼疮样皮肤病的德国短毛猫，两只雌性和一只雄性。两只狗还将用于繁殖以扩大殖民地，所有组织病理学评估均由委员会认证的兽医皮肤科医生和病理学家Elizabeth Mauldin博士进行。Mauldin博士和我申请并收到了诺华公司的一笔小额赠款，用于口服环孢素（Atopica）的治疗试验，这是一种免疫调节剂，被认为可以减少或消除真皮中的细胞反应，而这种反应似乎是导致疾病的原因。每月进行一次活检和拍照，治疗12个月后将总结结果并提交给诺华公司。研究结果将在研究完成后公布。我们还收到了许多皮肤活检和血液样本，从受影响的狗和他们的亲属组织病理学和DNA，分别