LUPOID DERMATOSIS

狼疮性皮肤病

• 批准号: 7391965
• 负责人: MARGRET L CASAL
• 金额: $ 0.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391965
• 关键词: LUPOID; DERMATOSIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An 11 moth old intact male German Short Hair Pointer presented with extremely flaky skin all over his whole body. The owner had reported that the dog had had the same appearance to his skin ever since the dog was obtained at 12 weeks of age. Despite all types of shampoos, steroids, and antibiotics, the condition remained the same. At times, the lesions on his nose and face would get worse, only to get better again, but would never resolve. On examination, the dog appeared physically healthy except for the dander covering his whole body. There were some crusty lesions on his nose and on his scrotum. Three biopsies from the forehead, thorax and lumbar region were obtained. There was hyperkeratosis and focal parakeratosis. Basal cell apoptosis was diffusely scattered throughout the tissues. There was also basal cell vacuolation and large numbers of melanophages within the dermis. There was a minimal lymphocytic infiltrate, which should he seen with lupus in dogs. However, on consultation with the dermatopathologists at the Hospital of the University of Pennsylvania, a diagnosis of lupus of the skin was confirmed. This dog was donated to the University of Pennsylvania. He is to be used for breeding to expand the colony. In the meantime, we have received three more German shorthair pointers that are affected with lupoid dermatosis, two females and one male. Both dogs are also to be used for breeding to expand the colony, All of the histopathological evaluations are being performed by Dr. Elizabeth Mauldin, a board certified veterinary dermatologist and pathologist. Dr Mauldin and I applied for and received a small grant from Novartis for therapeutic trials of oral cyclosporine (Atopica), an immune modulator thought to reduce or eliminate cellular reactions in the dermis, which appear to cause the disease. Biopsies and photographs are being taken at monthly intervals and the results will be summarized and presented to Novartis after 12 months of treatment. The results will be published after completion of the study. We have also received numerous skin biopsies and blood samples from affected dogs and their relatives for histopathology and DNA, respectively

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。一只11个月大的完好无损的雄性德国短毛犬，全身皮肤都非常松软。主人报告说，自从这只狗在12周大的时候获得以来，它的皮肤就一直保持着同样的外观。尽管使用了所有类型的洗发水、类固醇和抗生素，情况仍然是一样的。有时，他鼻子和面部的损伤会变得更糟，只会再次好转，但永远不会痊愈。经过检查，这只狗看起来身体很健康，除了全身都是皮屑。他的鼻子和阴囊上有一些硬壳状的损伤。取自额部、胸部和腰部的三份活检标本。角化过度和局灶性角化不全。基底细胞凋亡弥漫分布于各组织。真皮内也可见基底细胞空泡化和大量黑素噬菌体。有极少量的淋巴细胞渗入，这在狼疮犬身上可见。然而，在咨询了宾夕法尼亚大学医院的皮肤病理学家后，确诊为皮肤红斑狼疮。这只狗被捐赠给了宾夕法尼亚大学。他将被用来进行繁殖以扩大殖民地。与此同时，我们又收到了三名感染狼疮性皮肤病的德国短毛猎犬，两名女性和一名男性。这两只狗也将用于繁殖以扩大群体，所有的组织病理学评估都是由伊丽莎白·毛尔丁博士进行的，她是一名委员会认证的兽医皮肤科医生和病理学家。毛尔丁博士和我申请并从诺华公司获得了一小笔赠款，用于口服环孢素(Atopica)的治疗试验，这是一种免疫调节剂，被认为可以减少或消除真皮中似乎导致疾病的细胞反应。活检和照片每月进行一次，结果将在治疗12个月后汇总并提交给诺华公司。研究结果将在研究完成后公布。我们也收到了大量的皮肤活检和血液样本，分别来自受影响的狗只及其亲属的组织病理学和dna。