MOLECULAR GENETICS LABORATORY CHARACTERIZATION OF MODELS

分子遗传学实验室模型表征

• 批准号: 7391948
• 负责人: PAULA S HENTHORN
• 金额: $ 9.4万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391948
• 关键词: MOLECULAR; GENETICS; LABORATORY; CHARACTERIZATION; MODELS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Molecular Genetics Laboratory was developed for the purpose of isolating the genes involved in animal models of human disease, determining mutations responsible for specific diseases, and cloning relevant normal cDNAs for use in vector construction for therapeutic approaches. As such, this laboratory provides the definitive dimension in the ability to fully characterize models and establish their homology to the human disease. The availability of a complete 7.6X canine genome sequence, and the ongoing effort to produce a 2X feline genome sequence (approximately ¿ of the raw sequence data for this project is already available at NCBI Trace Archive: http://www.ncbi.nlm.nih.gov/Traces/trace.cgi?) has significantly enhances the our ability to provide molecular characterization of disease under study.

该主题项目是利用NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。开发了分子遗传学实验室，目的是隔离与人类疾病动物模型相关的基因，确定负责特定疾病的突变，并克隆相关的正常CDNA，以用于载体构造中，以用于治疗方法。因此，该实验室提供了完全表征模型并与人类疾病建立同源性的能力的确定维度。完整的7.6倍犬基因组序列的可用性以及生产2倍猫基因组序列的持续努力（该项目的原始序列数据大约可以在NCBI Trace Archive：http：//wwwwwww.ncbi.nlm.nlm.nih.gov/trace/trace/trace.cgi-cgi- provernortial nounder nounder Indor Indor norportive mornecrization nor Sorival Inder Inder norce nor norce insor Inder ander norce nor norce中提高了能力。