Understanding the impact of sex differences on immune responses

了解性别差异对免疫反应的影响

• 批准号: 2735126
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2735126
• 关键词: Understanding; impact; sex; differences; immune

Sex differences have shown to impact immune responses. A potential avenue for this difference could be in X chromosome inactivation, which results in either maternal X chromosome expression or paternal X chromosome expression. This causes a chromosomal mosaicism in women, possibly causing differences in immune response. This project will analyze RNAseq data to test this Hypothesis.BBSRC priority areas: Understanding the rules of life, Bioscience for an integrated understanding of health.

性别差异已被证明会影响免疫反应。这种差异的一个潜在途径可能是X染色体失活，这导致母亲X染色体表达或父亲X染色体表达。这会导致女性的染色体嵌合现象，可能导致免疫反应的差异。该项目将分析RNAseq数据来验证这一假设。BBSRC优先领域：了解生命的规则，生物科学对健康的综合理解。