Mechanistic Analysis and Development of Direct and Catalysed Coupling of Carboxylic Acids with Amines. Disentangling the Enigma

羧酸与胺的直接和催化偶联的机理分析和发展。

• 批准号: 2736069
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2736069
• 关键词: Mechanistic; Analysis; Development; Direct; Catalysed

The ability of some amine-acid combinations to generate amides from direct dehydrative coupling suggests there are other interactions occurring in this reaction which are unidentified. The mechanism of this process is not well understood with multiple unproven hypotheses. Similarly the influence of chemical specificity of the amine-acid pairs that react in this way altering the reaction kinetics are also unclear. This research project will apply the full physical organic toolbox to investigate these enigmatic processes to provide some insight into the underlying mechanism. The resulting information learned will be applied to formulate new optimum conditions catalysts and processes for efficient and 'clean' amide generation from amines and acids.

一些胺-酸组合从直接脱水偶联生成酰胺的能力表明在该反应中存在未鉴定的其他相互作用。这个过程的机制还没有很好地理解，有多个未经证实的假设。类似地，以这种方式反应的胺-酸对的化学特异性改变反应动力学的影响也不清楚。这个研究项目将应用完整的物理有机工具箱来研究这些神秘的过程，以提供一些深入了解潜在的机制。由此获得的信息将被应用于制定新的最佳条件催化剂和工艺，以有效和“清洁”的酰胺生成胺和酸。