Molecular Microbial Pathogenesis Training Program

分子微生物发病机制培训项目

• 批准号: 7083645
• 负责人: Fernando Villalta
• 金额: $ 11.15万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7083645
• 关键词: Molecular; Microbial; Pathogenesis; Training; Program

An emerging and reemerging infectious disease crisis exist throughout the world today. Further, bioterrorism using microbes or their products poses significant threat to the USA and the entire world. Because there is a national need for scientists with expertise and training in several areas of infectious diseases, in this fourth renewal application we are expanding the scope of our Molecular Parasitology Training Program into Molecular Microbial Pathogenesis Training Program to provide graduate training in pathogenesis of diseases caused by parasites, bacteria and viruses. There continues to be a need to increase the number of minority scientists who are conducting research in the area of tropical and infectious diseases. In order to address these issues we are requesting support to continue funding the Molecular Microbial Pathogenesis Training Program administered by the Department of Microbiology at Meharry Medical College. The proposed program will provide opportunity for training six African Americans or other graduate students who are committed to a career in infectious diseases. Twenty one core faculty members at Meharry Medical College and Vanderbilt University will participate in the proposed graduate training. The diseases to be investigated include, malaria, Leishmaniasis, African trypanosomiasis, American trypanosomiasis, AIDS, viral gastroenteritis and encephalitis, septic shock, endocarditis, periodontitis, and the emerging pathogens Mycobacterium tuberculosis Bartonella bacilliformis and Helicobacterpylori. Students in the program will meet the Ph.D. requirements of the graduate program at Meharry and the requirements of one of the three Ph.D. tracks in the Department of Microbiology: (i) microbiology and immunology; (ii) cell and molecular biology; and (iii) genetics. This training program will also include the yearly participation of the pre-doctoral students in a Tropical and Infectious Diseases Symposium which was initiated at Meharry in 1984 and continues to be the venue each Spring for outstanding research reports on recent advances in the biochemistry, molecular biology and immunology of Tropical and Infectious Diseases. Dr. Fernando Villalta, Professor in the Department of Microbiology at Meharry Medical College, will serve as a Program Director and will be responsible for the overall administration of the program. Dr. Maria F. Lima, Dean of the School of Graduate Studies at Meharry and member of this training program, will serve as a Co-Director together with Dr. Jacek Hawiger at Vanderbilt University. They will be assisted by the Molecular Microbial Pathogenesis Training Program Advisory Committee consisting of training faculty from Meharry and Vanderbilt as well as an External Advisory Committee. Each trainee's Committee on Instruction will include members of Meharry faculty and a faculty mentor from Vanderbilt. In addition, each trainee will take at least one didactic course at Vanderbilt and participate in training there as needed. All trainees and faculty in the program will participate in a seminar series that include presentations by faculty and students in the program. This is a strong research training program administered at an institution with an excellent record of recruiting and retaining minority students in graduate programs. The goals of the proposed training program will be enhanced by the increasing number of collaborative research and training programs at Meharry and Vanderbilt resulting from a formal alliance between the institutions in 1999. The support requested will provide unique opportunities for these students and provide a positive step to address the shortage of research on emerging infections as well as the shortage of minority scientists in this discipline.

当今世界存在着新出现和重新出现的传染病危机。此外，使用微生物或其产品的生物恐怖主义对美国和整个世界构成重大威胁。因为有一个国家需要的科学家的专业知识和培训在传染病的几个领域，在这第四次更新申请，我们正在扩大我们的分子寄生虫学培训计划的范围到分子微生物发病机制培训计划，以提供研究生培训疾病的发病机制引起的寄生虫，细菌和病毒。仍然需要增加在热带疾病和传染病领域进行研究的少数民族科学家的人数。为了解决这些问题，我们请求支持继续资助由Meharry医学院微生物学系管理的分子微生物发病机制培训计划。该计划将为六名非洲裔美国人提供培训机会， 其他致力于传染病事业的研究生。梅哈里医学院和范德比尔特大学的21名核心教员将参加拟议中的研究生培训。待调查的疾病包括疟疾、利什曼病、非洲锥虫病、美洲锥虫病、艾滋病、病毒性胃肠炎和脑炎， 感染性休克、心内膜炎、牙周炎以及新出现的病原体结核分枝杆菌、杆菌形巴尔通体和幽门螺杆菌。该项目的学生将与博士生见面。在Meharry研究生课程的要求和三个博士学位之一的要求。在微生物学系的轨道：（一）微生物学和免疫学;（二）细胞和 分子生物学;和（iii）遗传学。该培训计划还将包括博士生每年参加一次热带和传染病研讨会，该研讨会于1984年在Meharry发起，每年春季继续举办关于生物化学，分子生物学和热带和传染病免疫学最新进展的杰出研究报告。梅哈里医学院微生物学系教授Fernando Villalta博士将担任项目主任，负责该项目的整体管理。Maria F.博士利马是梅哈里研究生院院长，也是该培训项目的成员，他将与范德比尔特大学的Jacek Hawiger博士一起担任联合主任。他们将得到由Meharry和范德比尔特的培训教师以及外部咨询委员会组成的分子微生物发病机制培训计划咨询委员会的协助。每个学员的指导委员会将包括梅哈里教师和教师导师从范德比尔特的成员。此外，每个受训人员将在范德比尔特至少参加一个教学课程，并根据需要参加那里的培训。该项目的所有学员和教师将参加一系列研讨会，其中包括教师和学生在该项目中的演讲。这是一个强大的研究培训计划，在一个机构管理，在研究生课程中招募和留住少数民族学生的优秀记录。1999年，梅哈里和范德比尔特两个机构正式结盟，合作研究和培训方案的数量不断增加，这将加强拟议培训方案的目标。所要求的支持将为这些学生提供独特的机会，并提供一个积极的步骤，以解决对新出现的感染研究的短缺以及该学科少数民族科学家的短缺。