Molecular Pathogenesis of Infectious Diseases

描述(由申请人提供)：传染病的分子病理学是科罗拉多大学健康科学中心的一个由19名教员组成的跨部门小组非常感兴趣的领域。这是一个新兴的研究领域，包括微生物毒力因子的分子生物学和生化研究，宿主耐药机制，感染过程中基因表达的调控，在感染中发挥关键作用的微生物和宿主细胞分子的结构-功能分析，细菌和病毒与体外分化的宿主细胞的相互作用分析，以及转基因动物模型中转基因细菌和病毒感染的研究。我们的教员团队在这一领域的创新研究方面拥有公认的记录。这些教师正在培训21名博士前学生，让他们掌握了解并最终控制传染病所需的多学科方法。将由传染病分子病理学研究生培训基金资助的博士前学生将学习识别和解决在医学微生物学、分子结构、细胞与细菌和病毒的相互作用以及细菌和病毒疾病的体内分析方面的重要研究问题。科罗拉多大学医学院的高素质博士前学生在NIH资助的培训补助金教师的指导下从事细菌或病毒疾病的分子发病机制的研究，他们将在完成所有必修课程、通过初步和综合考试并开始论文研究后被选为培训补助金的受聘人员。我们要求在第一年申请4个博士后研究生职位，第二年申请5个，以后每一年申请6个。每个被选中的学生在论文研究期间将得到至少两年的培训补助金支持。研讨会、杂志俱乐部和研究进展会议的综合计划将训练学生识别重要的研究问题，使用各种分子、细胞和体内技术设计良好控制的实验，并对结果进行批判性评估和展示。科学交流技能和研究道德方面的培训是该计划的重要组成部分。这一综合的跨部门培训计划的广度将为学生在学术界或传染病发病机制重要领域的生物技术创新研究和教学方面的职业生涯做好准备。

DESCRIPTION (provided by applicant): The Molecular Pathogenesis of Infectious Diseases is an area of great interest to an interdepartmental group of 19 faculty members at the University of Colorado Health Sciences Center. This is a newly emerging area for research that encompasses molecular biological and biochemical studies on microbial virulence factors, host resistance mechanisms, regulation of gene expression during infection, structure-function analysis of microbial and host cell molecules that play key roles in infections, analysis of interactions of bacteria and viruses with differentiated host cells in vitro, and studies on infections with genetically modified bacteria and viruses in genetically modified animal models. Our faculty group has a proven record of innovative research in this area. The faculty are training 21 predoctoral students in the multidisciplinary approaches needed to understand and eventually control infectious diseases. Predoctoral students to be supported by the Molecular Pathogenesis of Infectious Diseases Graduate Student Training Grant will learn to identify and solve important research problems in medical microbiology, molecular structure, cellular interactions with bacteria and viruses, and in vivo analysis of bacterial and viral diseases. Highly qualified predoctoral students at the University of Colorado School of Medicine who are doing research on the molecular pathogenesis of bacterial or viral diseases with NIH-funded mentors on the training grant faculty will be selected for appointment to the training grant after they have completed all of their required courses, passed their preliminary and comprehensive examinations, and begun their dissertation research. We request 4 predoctoral student positions for the first year of the grant, 5 for the second year, and 6 for each successive year. Each selected student will be supported by the training grant for a minimum of 2 years during the period of dissertation research. A comprehensive program of seminars, journal clubs, and research-in-progress meetings will train the students to identify important research questions, design well-controlled experiments using a wide variety of molecular, cellular and in vivo techniques, and critically evaluate and present the results. Training in scientific communication skills and ethics in research are important components of the program. The breadth of this integrated, interdepartmental training program will prepare the students well for careers in innovative research and teaching in academia or biotechnology in the important area of the pathogenesis of infectious diseases.