Understanding pathogen and host determinants of the natural history of N. gonorrhoeae infection

摘要： 淋病奈瑟菌对抗生素耐药性的增加构成了严重的全球公共卫生威胁。 淋球菌的有效控制受到无症状感染的阻碍，这些感染允许 将细菌传播给未受感染的人，以及由符合以下条件的细菌免疫逃避 限制了疫苗开发的努力。了解无症状的自然病史 感染和负责清除感染的免疫反应。我们 建议进行一项密切监测的纵向研究，并对新近患N的患者进行随访。 淋病感染者是再次感染的高危人群。本研究将提供丰富的数据 以了解病原体暴露和感染结果。它还将提供一套生物 标本来研究有助于感染清除的病原体和宿主因素 无症状携带者和/或进展为症状性感染。我们将进行 抗N抗体分析。淋病抗体和细胞免疫反应告知相关人员 对淋病的保护性免疫。合并后的这个项目将提供重要的新 有助于公共卫生和疫苗开发工作的信息，以减少 淋病奈瑟菌的传播。

Abstract: Rising antibiotic resistance in N. gonorrhoeae poses a serious, global public health threat. Effective control of N. gonorrhoeae is hampered by asymptomatic infections that allow transmission of the bacteria to uninfected individuals and immune evasion by the bacteria that has limited vaccine development efforts. Understanding the natural history of asymptomatic infection and the immunologic responses that are responsible for clearance of infection. We propose a longitudinal study with close surveillance and of follow up individuals with recent N. gonorrhoeae infection who are at high risk for re-infection. This study will provide a rich data set to understand pathogen exposure and infection outcome. It will also provide a set of biologic specimens to study the pathogen and host factors that contribute to infection clearance as well as asymptomatic carriage and/or progression to symptomatic infection. We will conduct analysis of anti-N. gonorrhoeae antibody and cellular immune responses to inform correlates of protective immunity against gonorrhea. Combined this project will provide important new information that will contribute to public health and vaccine development efforts to reduce the spread of N. gonorrhoeae.