ROMP-Derived Oligomers for Faciliated Synthesis

描述（由申请人提供）：本研究是Materia，Inc.和堪萨斯大学专注于开发来自开环易位聚合（ROMP）的高负荷低聚试剂和清除剂，开环易位聚合是Materia公司的几种核心易位技术之一。第一阶段的具体目标集中在3个领域，均利用ROM聚合，包括：（1）开发一系列高负荷、低聚物清除剂;（2）开发一系列高负荷、低聚物试剂;（3）开发一系列高负荷、低聚物支持物，用于多步合成。使用ROM聚合，这些低聚物将被开发为具有各种可调性质，用于促进合成方案。I期研究产生的数据将用于II期研究，II期研究的重点是这些低聚物的商业化，用于药物发现中的促进合成方案。总的来说，这些低聚物的开发将在涉及整合合成和纯化的几个新的研究领域中开辟机会，包括聚合物对聚合物反应，高负荷可溶性低聚物的方便液体分配，以及由高负荷试剂支持的合成方案。

DESCRIPTION (provided by applicant): This Phase I Small Business Technology Transfer study between Materia, Inc. and the University of Kansas is focused on the development of high-load, oligomeric reagents and scavenging agents derived from ring-opening metathesis polymerization (ROMP), 1 of several core metathesis technologies at Materia, Inc. The specific aims during Phase I focus on 3 areas, all utilizing ROM polymerization, including: (1) the development of an array of high-load, oligomeric scavenging agents; (2) the development of an array of high-load, oligomeric reagents; (3) the development of an array of high-load, oligomeric supports for multi-step synthesis. Using ROM polymerization, these oligomers will be developed with an assortment of tunable properties for use in facilitated synthetic protocols. The data generated from Phase I studies will be utilized in Phase II studies which are focused on the commercialization of these oligomers for use in facilitated synthetic protocols in drug discovery. Taken collectively, the development of these oligomers will open opportunities in several new areas of research involving integrating synthesis and purification, including polymer-on-polymer reactions, convenient liquid dispensing of high-load, soluble oligomers, and supported synthetic protocols enabled by high-load reagents.