2009 Combinatorial Chemistry Gordon Research Conference

描述（由申请人提供）：本申请的目的是寻求NIH资助，以支持2009年首届题为“组合化学：高通量化学和化学生物学”的戈登-凯南研究生研究研讨会（GRS）。GRS将于2009年6月6日至7日在美国新罕布什尔州科尔比-索耶学院举行，与此同时，2009年戈登组合化学会议（高通量化学和化学生物学）将于6月7日至12日在新罕布什尔州科尔比-索耶学院举行。整个GRC由宾夕法尼亚州费城Cephalon公司的Joseph M. Salvino博士担任主席，马萨诸塞州波士顿Broad研究所的Mike Foley博士担任副主席。本次GRS将为年轻的研究人员提供机会，展示他们在该领域前沿的前沿研究成果，引发刺激的互动和辩论。这将通过为期1.5天的会议来体现，其中包括10名学生/博士后研究员的演讲，两次海报会议和该领域杰出领导者的重点演讲。总而言之，GRS的目标是50名年轻的研究人员出席，在轻松的氛围中提供优秀的科学论坛。贾里德·肖博士（加州大学戴维斯分校）将成为2009年首届GRS主题演讲嘉宾。肖博士的研究体现了这一领域当前努力的广度。Jared从Broad研究所出来，在Broad研究所所长Stuart Schreiber教授的指导下工作。2006年秋天，他在加州大学戴维斯分校开始了独立的职业生涯。主要研究方向为合成方法论、天然产物合成、生物多样性合成和化学生物学。他的演讲将是GRS唯一的教师演讲，其余的由学生/博士后研究员的演讲组成。两个海报环节将向所有参与者开放，他们将有机会在随后的大型GRC（视频基础设施）中展示他们的海报。这一首个GRS的发展将为该领域的资深科学家与学生和博士后研究人员互动提供前所未有的机会，并将加强学生学习该领域及其所包含的新技术之间的联系。组合化学GRC有一个强大的传统，积极参与少数民族参与者，妇女和残疾学生，这一趋势将继续下去。卡尔·斯托姆少数民族和国际多样性奖学金计划将用于加强目前的筹资努力。最终，GRS将提供一个极好的论坛，以弥合充满热情和新鲜想法的年轻研究者与每天使用该技术的经验丰富的研究人员之间的差距。

DESCRIPTION (provided by applicant): The purpose of this application is to seek NIH funds to support the inaugural 2009 Gordon-Kenan graduate research seminar (GRS) entitled Combinatorial Chemistry: High Throughput Chemistry and Chemical Biology. The GRS will be held at Colby-Sawyer College, NH, USA from June 6-7, 2009, in conjunction with the 2009 Gordon Conference in Combinatorial Chemistry (High Throughput Chemistry and Chemical Biology) to be held from June 7-12th at Colby-Sawyer College, NH. The full GRC is chaired by Dr. Joseph M. Salvino at Cephalon, Inc. in Philadelphia, PA and vice-chaired by Dr. Mike Foley at the Broad Institute in Boston, MA. This GRS will provide young investigators the opportunity to present their efforts on cutting edge research at the forefront of the field, provoking stimulating interaction and debate. This will be manifested via a 1.5-day conference comprised of 10 student/postdoctoral researcher talks, two poster sessions and a Key Note address from an outstanding leader in this field. In all, the GRS is targeting an attendance of 50 young investigators providing an excellent scientific forum in a relaxed atmosphere. Dr. Jared Shaw (UC Davis) will be the inaugural GRS 2009 Keynote speaker. Dr. Shaw's research embodies the breadth of current efforts in this field. Jared emerged from the Broad Institute, working under the mentorship of the Professor Stuart Schreiber who is Director of the Broad Institute. He began his independent career at UC Davis in the fall of 2006. His research interests span synthetic methodology, natural product synthesis, diversity-oriented synthesis and chemical biology. His talk will be the only faculty talk at the GRS, the remainder comprised of student/postdoctoral researcher talks. The two poster sessions will be open to all participants who will have opportunity to also present their posters during the larger GRC to follow, vide infra. The development of this inaugural GRS will provide an unprecedented opportunity for senior scientists in the field to interact students and postdoctoral researchers and will strengthen the link between students learning about this field and the new technology it encompasses. The GRC on Combinatorial Chemistry has a Strong tradition of actively involving minority participants, women and students of disability, and this trend will be continued. The Carl Storm Minority and International Diversity Fellowship Program will be utilized to augment current funding efforts. Ultimately, the GRS will provide an excellent forum to bridge the gap between the young investigator full of enthusiasm and fresh ideas, and the seasoned researchers who utilize the technology on a daily basis. PUBLIC HEALTH RELEVANCE: The demand for high quality libraries of small molecules for use in high-throughput screening (HTS) has presented enormous challenges and opportunities at the forefront of molecular library development and chemical biology. Ultimately, solutions to these challenges serve to uncover molecular leads as potential therapeutic agents aimed at improving human health. 1