Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis

描述(申请人提供)：本建议的长期目标是开发新的组合物(S)，用于预防治疗/预防敏感个体的毒藤接触性皮炎。毒藤/毒橡树和另一种近缘物种毒漆树是美国户外工作者职业危害的主要原因。今天市场上的大多数产品都是为了在接触这些植物之前应用一种化学屏障，或者针对皮炎的对症治疗。本申请中建议的产品将用于治疗从未接触过毒藤的个人，从而诱导这些个人的耐受性(相当于免疫接种)和/或预防性治疗已经敏感的个人，可能在每个季节之前使用一次注射。因此，这项提议的目的将是制备(合成)具有增强的物理和配方特征的不同的衍生物，在豚鼠动物模型中测试这些产品(或至少一种选定的制剂)作为概念验证的有效性。这项工作的结果将成为第二阶段应用的基础，旨在优化配方、剂量和给药途径，并进行稳定性、药代动力学和临床前毒理学/开发活动。这项建议解决了一个主要的公共卫生问题，即接触性过敏性皮炎，并承诺开发一种有效的试剂来解决这一问题。

DESCRIPTION (provided by applicant): The long term objectives of this proposal are aimed at the development of new composition(s) to be used for the prophylactic treatment/prevention of poison ivy contact dermatitis in sensitive individuals. Poison ivy/poison oak and another related species poison sumac are the main cause of occupational hazards for outdoor workers in the United States. Most of the products on the market today are aimed at applying a chemical barrier prior to being exposed to these plants or directed toward symptomatic treatment of the dermatitis. The products proposed in this application will be directed towards treatment of individuals who have never been exposed to poison ivy and therefore inducing tolerance in these individuals (equivalent to immunization) and/or towards prophylactic treatment of already sensitive individuals, perhaps using a single injection prior to each season. The aims, therefore of this proposal will be to prepare (synthesize) different derivatives with enhanced physical and formulation characteristics, testing of these products (or at least 1 selected agent) in the guinea pig animal model for efficacy as a proof of concept. The results of this work will form the basis for a Phase II application directed toward optimization of formulation, dosage and route of administration as well as carrying out stability, pharmacokinetics and preclinical toxicology/developmental activities. This proposal addresses a major public health problem, namely contact allergic dermatitis and promises the development of an effective agent to address this problem.