AFFINITY REAGENTS FOR THE IMMUNE SYSTEM OF GUINEA PIGS

为了满足针对豚鼠细胞因子的单抗的需求，要约人建议生产针对Th1和Th2细胞因子的抗体试剂。他们将在体外表达豚鼠重组细胞因子，利用他们建立的新技术为每个选定的细胞因子产生兔单抗，生产和验证兔单抗。这些高亲和力的单抗对豚鼠Th1和Th2细胞因子的可获得性将有助于在包括结核病、寨卡病毒感染、埃博拉和流感研究在内的传染病领域使用该动物模型进行免疫学分析。

To address the need of monoclonal antibodies (MAbs) targeting guinea pig cytokines, the Offeror proposes to generate antibody reagents for Th1 and Th2 cytokines. They will express guinea pig recombinant cytokines in vitro, generate rabbit MAbs for each selected cytokine using their established novel technology, produce and verify rabbit MAbs. The availability of these high affinity MAbs to guinea pig Th1 and Th2 cytokines will facilitate the immunological analysis using this animal model in the field of infectious diseases including studies in tuberculosis, zika viral infection, Ebola and influenza