AFFINITY REAGENTS FOR THE IMMUNE SYSTEM OF GUINEA PIGS

为了解决靶向豚鼠细胞因子的单克隆抗体（MAb）的需求，要约人提出产生用于Th1和Th2细胞因子的抗体试剂。他们将在体外表达豚鼠重组细胞因子，使用其建立的新技术产生针对每种选定细胞因子的兔单克隆抗体，生产并验证兔单克隆抗体。这些对豚鼠Th1和Th2细胞因子的高亲和力MAb的可用性将促进在传染病领域中使用该动物模型的免疫学分析，所述传染病领域包括结核病、寨卡病毒感染、埃博拉病毒和流感的研究

To address the need of monoclonal antibodies (MAbs) targeting guinea pig cytokines, the Offeror proposes to generate antibody reagents for Th1 and Th2 cytokines. They will express guinea pig recombinant cytokines in vitro, generate rabbit MAbs for each selected cytokine using their established novel technology, produce and verify rabbit MAbs. The availability of these high affinity MAbs to guinea pig Th1 and Th2 cytokines will facilitate the immunological analysis using this animal model in the field of infectious diseases including studies in tuberculosis, zika viral infection, Ebola and influenza