AFFINITY REAGENTS FOR THE IMMUNE SYSTEM OF GUINEA PIGS

豚鼠免疫系统的亲和试剂

• 批准号: 10291473
• 负责人: HONG QI
• 金额: $ 30万
• 依托单位: QOOLABS, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10291473
• 关键词: Address; Affinity; Animal Model; Antibodies; Cavia; Cells; Communicable Diseases; Ebola; Immune system; Immunologics; In Vitro; Influenza; Monoclonal Antibodies; Oryctolagus cuniculus; Production; Reagent; Recombinant Cytokines; Tuberculosis; ZIKV infection; cytokine; new technology

To address the need of monoclonal antibodies (MAbs) targeting guinea pig cytokines, the Offeror proposes to generate antibody reagents for Th1 and Th2 cytokines. They will express guinea pig recombinant cytokines in vitro, generate rabbit MAbs for each selected cytokine using their established novel technology, produce and verify rabbit MAbs. The availability of these high affinity MAbs to guinea pig Th1 and Th2 cytokines will facilitate the immunological analysis using this animal model in the field of infectious diseases including studies in tuberculosis, zika viral infection, Ebola and influenza

为了解决针对豚鼠细胞因子的单克隆抗体（mab）的需求，要约公司建议生产针对Th1和Th2细胞因子的抗体试剂。他们将在体外表达豚鼠重组细胞因子，利用他们建立的新技术为每种选定的细胞因子生成兔单抗，生产和验证兔单抗。这些对豚鼠Th1和Th2细胞因子具有高亲和力的单克隆抗体的可用性，将有助于在传染病领域使用这种动物模型进行免疫学分析，包括结核病、寨卡病毒感染、埃博拉和流感的研究