Seattle Cancer and Aging Program

（申请人描述）西雅图癌症与衰老项目是Fred Hutchinson癌症研究中心和华盛顿大学Nathan Shock中心对衰老研究的协调响应，旨在探索癌症与衰老的联系。本提案是一项研究规划和发展拨款申请，用于支持扩大我们nci指定的癌症中心的能力，以从事专注于人类癌症的衰老和与年龄相关方面的研究。我们的目标是支持研究和教育活动，以促进建立一个正式的跨学科老龄化/癌症研究“项目”，作为我们nci资助的癌症中心支持基金（CCSG）的组成部分。为了实现这一目标，我们计划资助一系列试点项目，这些项目将促进新的合作，产生有希望的研究成果，催化新的独立研究资助，并为癌症和衰老的持续统一研究奠定基础。弗雷德·哈钦森癌症研究中心和华盛顿大学组成的联盟通常拥有一支强大而多样化的教师队伍，他们对老龄化和癌症感兴趣，他们将能够利用这种支持。在我们最初的一系列试点项目中，我们首先专注于衰老和癌症生物学的主题领域；如提案所示，未来拟议的试点涉及所有七个专题支助领域。我们相信，我们处于一个独特的位置，可以打造一个互动的、一流的癌症和衰老项目。我们有幸拥有一流的研究人员，最先进的资源，以及坚如磐石的机构承诺，使这个项目取得成功。我们完全期望本提案中概述的活动将导致重要的发现，并为未来的重大科学努力奠定基础。

DESCRIPTION: (Applicant's Description) The Seattle Cancer and Aging Program is a coordinated response between the Fred Hutchinson Cancer Research Center and the University of Washington Nathan Shock Center for aging research to explore the connection of cancer and aging. This proposal is a research planning and development grant application to support activities that will expand the capacity of our NCI-designated Cancer Center to engage in research that concentrates on aging- and age-related aspects of human cancer. Our goal is to support research and educational activities that will promote the establishment of a formal interdisciplinary aging/cancer research "Program" as a component of our NCI-funded Cancer Center Support Grant (CCSG). To achieve this goal we plan to fund a series of pilot projects that will foster new collaborations, yield promising research results, catalyze new independent research grants, and lay the foundation for a continuing unified research effort in cancer and aging. The consortium of the Fred Hutchinson Cancer Research Center and the University of Washington has an usually strong and diverse faculty with aging and cancer interest who will be able to take advantage of this support. In our initial series of pilot projects we first concentrate on the thematic area of the Biology of Aging and Cancer; as demonstrated in the proposal, future proposed pilots involve all of the seven thematic areas of support. We believe we are in an unique position to forge an interactive, top-rate cancer and aging program. We are blessed with top-rate researchers, state-of-the-art resources, and rock-solid institutional commitment to make this a successful program. We fully expect that the activities outlined in this proposal will lead to important discovery and lay the foundation for significant scientific effort in the future.