Nathan Shock Ctr of Excellence in Basic Biology of Aging

描述(由申请者提供)：本申请书是关于续签华盛顿大学内森·霍克衰老基础生物学卓越中心的申请。在过去的10年里，该中心为研究该地区老龄化基础生物学的大批研究人员提供了资源。我们为广泛的外部资助、同行评审的研究项目提供服务，从中心到个人研究人员拨款。我们的更新建议包括一个资源核心，包括3个组成部分：1)转基因动物模型开发资源核心；2)细胞计数资源核心；3)功能基因组学资源核心。在下一个资助期，转基因动物模型开发资源核心将致力于开发和应用转基因发育和外源调控的结构。我们将继续我们的理念，帮助大量的研究人员为衰老研究开发小鼠模型。除了流式细胞术和细胞分类外，细胞学核心还将提供共聚焦显微镜和激光捕获显微切割服务。功能基因组学核心是我们基因表达核心的发展，将为转录组学、蛋白质组学和代谢组学提供专家帮助。研究发展核心将继续支持衰老基础生物学方面的试验性研究项目。计划充实核心支持行政管理、外部咨询小组以及课程和研讨会计划。

DESCRIPTION (provided by applicant): This application is for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington. This Center has over the past 10 years provided resources in support of the large community of investigators that study the basic biology of aging in this region. We serve a broad spectrum of externally funded, peer-reviewed research programs, ranging from Centers to individual investigator grants. Proposed components of our renewal include a Resources Core with 3 components: 1) Transgenic Animal Model Development Resource Core; 2) Cytometry Resource Core; 3) Functional Genomics Resource Core. In this next funding period, the Transgenic Animal Model Development Resource Core will work to develop and apply constructs for developmental and exogenous regulation of transgenes. We will continue our philosophy of helping a large number of investigators to develop mouse models for aging studies. The Cytometry Core will provide confocal microscopy and laser capture microdissection services in addition to flow cytometry and cell sorting. The Functional Genomics Core is the evolution of our Gene Expression core and will provide expert assistance for transcriptomics, proteomics and metabolomics. The Research Development Core will continue to support pilot study projects in the basic biology of aging. The Program Enrichment Core supports administrative management, an external advisory panel, and a program of courses and seminars.