Nathan Shock Ctr of Excellence in Basic Biology of Aging

描述（由申请人提供）：本申请是在华盛顿大学的老化基础生物学的内森休克卓越中心的更新。在过去的10年里，该中心提供了资源，支持研究该地区衰老基础生物学的大型研究人员社区。我们服务于广泛的外部资助，同行评审的研究计划，从中心到个人研究者赠款。我们更新的建议组件包括一个包含3个组件的资源核心：1）转基因动物模型开发资源核心; 2）细胞计数资源核心; 3）功能基因组学资源核心。在下一个资助期内，转基因动物模型开发资源核心将致力于开发和应用转基因发育和外源调控的构建体。我们将继续我们的理念，帮助大量的研究人员开发小鼠模型进行衰老研究。除了流式细胞术和细胞分选外，Cytometry Core还将提供共聚焦显微镜和激光捕获显微切割服务。功能基因组学核心是我们基因表达核心的演变，将为转录组学，蛋白质组学和代谢组学提供专家帮助。研究发展中心将继续支持老龄化基础生物学的试点研究项目。该计划丰富的核心支持行政管理，外部咨询小组，以及课程和研讨会计划。

DESCRIPTION (provided by applicant): This application is for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington. This Center has over the past 10 years provided resources in support of the large community of investigators that study the basic biology of aging in this region. We serve a broad spectrum of externally funded, peer-reviewed research programs, ranging from Centers to individual investigator grants. Proposed components of our renewal include a Resources Core with 3 components: 1) Transgenic Animal Model Development Resource Core; 2) Cytometry Resource Core; 3) Functional Genomics Resource Core. In this next funding period, the Transgenic Animal Model Development Resource Core will work to develop and apply constructs for developmental and exogenous regulation of transgenes. We will continue our philosophy of helping a large number of investigators to develop mouse models for aging studies. The Cytometry Core will provide confocal microscopy and laser capture microdissection services in addition to flow cytometry and cell sorting. The Functional Genomics Core is the evolution of our Gene Expression core and will provide expert assistance for transcriptomics, proteomics and metabolomics. The Research Development Core will continue to support pilot study projects in the basic biology of aging. The Program Enrichment Core supports administrative management, an external advisory panel, and a program of courses and seminars.