Functional Aging of the Inner Ear Sensory Systems

内耳感觉系统的功能老化

• 批准号: 7155895
• 负责人: Bruce Elliott Mock
• 金额: $ 3.05万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155895
• 关键词: age difference; aging; auditory threshold shift; biological models; evoked potentials; gender difference; genetic strain; genetic susceptibility; hearing; hearing disorders; hearing tests; laboratory mouse; labyrinth; model design /development; oscillography; otoacoustic emission; predoctoral investigator; proprioception /kinesthesia; sensory disorders; sensory signal detection; sound perception; stimulus /response; vestibular apparatus; vestibular pathway; vestibuloocular reflex

DESCRIPTION (provided by applicant): The broad, long-term objective of this research is to understand age-related changes in auditory and vestibular modalities in health and disease. Much is known about auditory aging, relatively little about vestibular aging and even less comparing the two systems. We hypothesize that functional aging of one inner ear sensory system does not obligate change in the other and genetic background and/or gender may influence vestibular and auditory aging. The proposed work will test these hypotheses using inbred mouse strains. Specific aim 1 will characterize age related changes in auditory and vestibular function and will compare the changes between the two sensory systems across the lifespan in 4 strains with different genetic backgrounds. We will record distortion product otoacoustic emissions (DPOAEs), auditory brainstem responses (ABR), and vestibular evoked potentials (VsEP) at monthly ages from 2 to 18 months. Specific aim 2 will compare inner ear functional aging between males and females. This work will lead to a better understanding of inner ear aging and predisposing factors (genetic and gender) for age related changes in vestibular and auditory function. The work will form the fundamental basis for future studies of anatomical or molecular correlates for inner ear aging and peripheral influences on aging of the central nervous system. Ultimately, the work may lead to better diagnosis and treatment of age related hearing loss and dizziness.

描述（由申请人提供）：这项研究的广泛，长期目标是了解与年龄相关的听觉和前庭方式变化。关于听觉衰老的了解，对前庭衰老相对较少，甚至比较两个系统。我们假设一个内耳感官系统的功能老化并不在另一个内部的遗传背景和/或性别可能会影响前庭和听觉衰老。提出的工作将使用近交小鼠菌株检验这些假设。特定的目标1将表征听觉和前庭功能与年龄相关的变化，并将比较4种具有不同遗传背景的4个菌株中两个感觉系统之间的变化。我们将在每月2到18个月的月度记录失真产物耳声排放（DPOAE），听觉脑干反应（ABR）和前庭诱发电位（VSEP）。特定的目标2将比较男性和女性之间的内耳功能老化。这项工作将使对前庭和听觉功能相关的年龄变化的内耳衰老和诱发因素（遗传和性别）更好地理解。这项工作将构成对内耳衰老和外围影响中枢神经系统衰老的解剖学或分子相关的未来研究的基本基础。最终，这项工作可能会导致更好地诊断和治疗与年龄相关的听力损失和头晕。