Cooperation between compartments during organ growth

器官生长过程中区室之间的合作

• 批准号: 7064083
• 负责人: Marcus L Vargas
• 金额: $ 4.09万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-09 至 2011-01-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7064083
• 关键词: Drosophilidae; arthropod genetics; cell death; cell growth regulation; cell morphology; developmental genetics; gene expression; histogenesis; imaginal disc; microarray technology; morphology; predoctoral investigator; protooncogene; transcription factor

DESCRIPTION (provided by applicant): Size regulation requires both extrinsic and intrinsic mechanisms that define growth limits. Extrinsic mechanisms sense nutrient availability and control growth systemically. In contrast, intrinsic mechanisms regulate growth in individual organs and tissues in an autonomous manner. It has been postulated that one way intrinsic size regulation of organs is achieved is through organ compartmentalization. The aim of this proposal is to investigate how developmental compartments contribute to organ growth and size. Expression of dMyc in the Posterior (P) compartment of the imaginal disc results in a proportionately normal size wing. We have found that cell death is increased within the P compartment, and also non-autonomously, in the Anterior (A) compartment in this case which might account for the proper size regulation. I propose studies to examine the role of cell death in regulation of the size of each compartment, and of the entire developing wing. Our results point to a possible asymmetry in growth regulation imposed by compartments. I propose experiments to address whether asymmetry exists and the possible mechanisms involved in this potential asymmetry.

描述（由申请人提供）：规模监管需要外在和内在机制来定义增长极限。外源机制感知养分的有效性，系统地控制生长。相反，内在机制以自主的方式调节个体器官和组织的生长。据推测，器官的内在大小调节的一种方式是通过器官区室化来实现的。这项建议的目的是研究发育区室如何有助于器官的生长和大小。dMyc在成虫盘的后（P）室中的表达导致成比例的正常大小的翼。我们发现，在这种情况下，P室中的细胞死亡增加，并且在前（A）室中也是非自主的，这可能解释了适当的大小调节。我建议研究细胞死亡的作用，在调节每个隔间的大小，整个发展中的翅膀。我们的研究结果表明，车厢施加的生长调节可能不对称。我提出的实验，以解决是否存在不对称性和可能的机制，在这种潜在的不对称性。