Cooperation between compartments during organ growth

描述（由申请人提供）：尺寸调节需要确定生长极限的外在和内在机制。外在机制感知养分的可用性并系统地控制生长。相反，内在机制以自主的方式调节单个器官和组织的生长。人们一直认为，实现器官内在大小调节的一种方式是通过器官区隔化。本研究的目的是研究发育区室对器官生长和大小的影响。dMyc在影像椎间盘后腔室的表达导致成比例正常大小的机翼。我们发现细胞死亡在P室增加，在这种情况下，在前(A)室也非自主地增加，这可能解释了适当的大小调节。我建议研究细胞死亡在每个隔室和整个发育翼的大小调节中的作用。我们的研究结果指出，在生长调节中可能存在不对称性。我建议通过实验来解决不对称是否存在以及这种潜在不对称的可能机制。

DESCRIPTION (provided by applicant): Size regulation requires both extrinsic and intrinsic mechanisms that define growth limits. Extrinsic mechanisms sense nutrient availability and control growth systemically. In contrast, intrinsic mechanisms regulate growth in individual organs and tissues in an autonomous manner. It has been postulated that one way intrinsic size regulation of organs is achieved is through organ compartmentalization. The aim of this proposal is to investigate how developmental compartments contribute to organ growth and size. Expression of dMyc in the Posterior (P) compartment of the imaginal disc results in a proportionately normal size wing. We have found that cell death is increased within the P compartment, and also non-autonomously, in the Anterior (A) compartment in this case which might account for the proper size regulation. I propose studies to examine the role of cell death in regulation of the size of each compartment, and of the entire developing wing. Our results point to a possible asymmetry in growth regulation imposed by compartments. I propose experiments to address whether asymmetry exists and the possible mechanisms involved in this potential asymmetry.