Cooperation between compartments during organ growth

器官生长过程中区室之间的合作

• 批准号: 7177549
• 负责人: Marcus L Vargas
• 金额: $ 4.09万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-09 至 2011-01-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7177549
• 关键词: Accounting; Address; Anterior; Biological Models; Cell Death; Cell Death Induction; Cells; Development; Drosophila melanogaster; Fellowship; Growth; Individual; Insulin; Names; Nutritional; Organ; Organ Size; Organism; Regulation; Role; Signal Pathway; Tissues; Wing; Work; detection of nutrient; imaginal disc; in vivo; prevent; research study; size

DESCRIPTION (provided by applicant): Size regulation requires both extrinsic and intrinsic mechanisms that define growth limits. Extrinsic mechanisms sense nutrient availability and control growth systemically. In contrast, intrinsic mechanisms regulate growth in individual organs and tissues in an autonomous manner. It has been postulated that one way intrinsic size regulation of organs is achieved is through organ compartmentalization. The aim of this proposal is to investigate how developmental compartments contribute to organ growth and size. Expression of dMyc in the Posterior (P) compartment of the imaginal disc results in a proportionately normal size wing. We have found that cell death is increased within the P compartment, and also non-autonomously, in the Anterior (A) compartment in this case which might account for the proper size regulation. I propose studies to examine the role of cell death in regulation of the size of each compartment, and of the entire developing wing. Our results point to a possible asymmetry in growth regulation imposed by compartments. I propose experiments to address whether asymmetry exists and the possible mechanisms involved in this potential asymmetry.

描述(由申请人提供)：大小调节需要外在和内在两种机制来定义增长限制。外在机制感知养分的有效性，并系统地控制生长。相反，内在机制以一种自主的方式调节单个器官和组织的生长。据推测，器官内部大小调节的一种方式是通过器官区划。这项提议的目的是调查发育间隔如何影响器官的生长和大小。DMyc在假想的椎间盘后(P)间隙的表达导致了一个比例正常的翅膀大小。我们发现，在这种情况下，细胞死亡在P间隔内增加，在前(A)间隔也非自主地增加，这可能解释了适当的大小调节。我建议进行研究，以考察细胞死亡在调节每个隔室和整个发育翼的大小中所起的作用。我们的结果指出，隔间对生长的调控可能存在不对称性。我建议进行实验来解决是否存在不对称性，以及这种潜在的不对称性所涉及的可能机制。